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MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
TranscriptomicsTranscription profiling of micro-RNA genes in human papillary thyroid carcinoma
We show that numerous miRNAs are transcriptionally up-regulated in papillary thyroid carcinoma (PTC) tumors compared with unaffected thyroid tissue. Among the predicted target genes of the three most upregulated miRNAs (miRs 221, 222 and 146b), only less than 15% showed significant downexpression i...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-3467 | biostudies-arrayexpress
ProteomicsShotgun proteomics of thyroid carcinoma exosomes: insight into the role of exosomal proteins in carcinogenesis and thyroid homeostasis
The transport of molecules via exosomes is one of the factors involved in cancer development, and transferred molecules can serve as specific tumor biomarkers. The aim of the study was the LC MS/MS proteomic analysis of exosomes released by FTC and 8305C thyroid cancer cell lines, and reference Nthy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-19 | MSV000093152 | MassIVE
ProteomicsComparative proteomic profiling of ectosomes derived from thyroid carcinoma and normal thyroid cells uncovers multiple proteins with functional implications in cancer
Proteins carried by tumor-derived ectosomes play an important role in cancer progression and are considered promising diagnostic markers. In the present study a shotgun nanoLC-MS/MS proteomic approach was applied to profile and compare the protein content of ectosomes released in vitro by normal hum...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-17 | MSV000088850 | MassIVE
TranscriptomicsPrimary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis
Comprehensive gene expression profiles of four Primary T-cell lymphomas of the thyroid were analyzed to detect tumor-specific genes. The gene expression profiles of CD4 positive T-lymphocytes from normal donor were analyzed as control samples.
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1411 | biostudies-arrayexpress
TranscriptomicsAnalysis of transcriptome in ectopic versus orthotopic thyroid tissue.
Congenital hypothyroidism from thyroid dysgenesis (CHTD) is a sporadic disease characterized by defects in the differentiation, migration or growth of thyroid tissue. Of these defects, incomplete migration resulting in ectopic thyroid tissue is the most common (up to 80%). We obtained flashfrozen sa...
ORGANISM(S): Homo sapiens 
2010-10-28 | E-GEOD-16804 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of human papillary thyroid carcinomas
RNA-Sequencing analysis of 18 papillary thyroid carcinoma biopsies and of 4 healthy donors' thyroids. In this analysis we assessed differential gene expression and investigated the mutational landscape in this tumor type. Analysis of gene fusion was also performed, leading to the identification of a...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-64912 | biostudies-arrayexpress
TranscriptomicsGene expression profile of normal thyroid tissue as indicator of thyroid carcinoma during thyroidectomy
In the present study, we examine expression profiles of normal tissue fragments, intraoperatively taken on the basis of macroscopic judgment and confirmed by immunohistochemistry, from patients with neoplastic and non-neoplastic disease of thyroid. The distinct GEP detected may influence the insurge...
ORGANISM(S): Homo sapiens 
2016-05-06 | E-MTAB-3796 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in Follicular Thyroid Adenomas and Carcinoma
The experiment was performed to identify differentially expressed microRNAs in follicular thyroid carcinoma and adenoma vs. normal thyroid tissue to explore possible common features in the proliferation stages. Furthermore comparisons between the carcinoma and adenoma were performed to search for di...
ORGANISM(S): Homo sapiens 
2011-11-30 | E-MTAB-736 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human thyroid gland cells to find molecular signatures of thyroid follicular neoplasia
Sixty-nine (69) tumor samples were collected from patients who underwent thyroidectomy.

The tumors included 22 benign follicular adenomas, 18 follicular carcinomas, 12 samples of microfollicular adenomas, 4 anaplastic carcinomas, 2 papillary carcinomas, and 9 nodular goiters. 23 samples were ...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-MEXP-2442 | biostudies-arrayexpress
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