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ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
ProteomicsArtificial intelligence defines protein-based classification of thyroid nodules
We applied PCT-DIA on a total of 1161 nodules from 1133 patients using either tissue cores (1 mm diameter; 0.5–1 mm depth) punched from regions of interest marked on retrospective FFPE tissue blocks or prospective cytology specimens from FNA aspirates. The samples comprise (i) a discovery set of FFP...
ORGANISM(S): Homo Sapiens 
2022-09-07 | PXD036554 |
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