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MetabolomicsSemaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14295 | MetaboLights
ProteomicsMuscle-derived extracellular vesicles transport glycolysis enzyme to mediate muscle-to-bone crosstalk
Identification of cues from skeletal muscle that control bone formation is essential for understanding the crosstalk between muscle and bone and for developing novel therapeutics for degenerative bone diseases. Here, we identified that skeletal muscle secreted abundant extracellular vesicles (Mu-EVs...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-19 | PXD040363 | Pride
Skeletal muscle extracellular vesicles glycolysis 
UnknownMechanism of genome instability mediated by human DNA polymerase mu misincorporation.
Not available
S-EPMC8213813 | biostudies-literature
ProteomicsSemaglutide targets mitochondria to regulate metabolism and inflammation in sarcopenia and osteoarthritis
Metabolic and inflammatory diseases often coexist, and become important challenges facing global health. As a traditional anti-obesity drug, semaglutide is reported to have therapeutic effects in sarcopenia and osteoarthritis (OA), but its mechanism of action still needs to be explored. Here we empl...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-06 | PXD073074 | Pride
C2c12 Semaglutide Mitochondria 
UnknownTianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain.
Not available
S-EPMC10517169 | biostudies-literature
MetabolomicsSemaglutide targets muscle mitochondria to regulate osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14059 | MetaboLights
UnknownTranscriptome Analysis and Reactive Oxygen Species Detection Suggest Contrasting Molecular Mechanisms in Populus canadensis' Response to Different Formae Speciales of Marssonina brunnea.
Not available
S-EPMC10815367 | biostudies-literature
UnknownOptimization of a static headspace GC-MS method and its application in metabolic fingerprinting of the leaf volatiles of 42 citrus cultivars.
Not available
S-EPMC9772436 | biostudies-literature
UnknownComparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases.
Not available
S-EPMC4009204 | biostudies-literature
ProteomicsA novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional control in humans and mice
Meiotic recombination ensures proper chromosome segregation and genetic diversity during gametogenesis, and its disruption leads to infertility. It is known that the dual histone methylation writer–reader system, in which PRDM9 deposits H3K4me3 and H3K36me3 marks at nucleosomes to specify recombinat...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD070427 | Pride
Meiotic recombination  zcwpw1–zcwpw2 complex  prdm9/zcwpw1/zcwpw2 system  ldha  ep300  lactylation 
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