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ProteomicsAc-IP tag enables multiplexed proteome quantification in data-independent acquisition mode
We propose the isotopically labeled Ac-IP (acetyl-isoleucine-proline) tag for multiplexed quantification of peptides at the MS1 level in the data-independent acquisition (DIA) mode. Differentially labeled peptides have distinct precursor ions carrying the quantitative information but identical MS2 s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-06-07 | PXD022606 | Pride
Quantitative proteomics Isotope labeling Data-independent acquisition 
ProteomicsA Versatile Isobaric Tag Enables Proteome Quantification in Data Dependent and Data Independent Acquisition Mode
Quantifying proteins based on peptide-coupled reporter-ions is a leading multiplexed quantitative strategy in proteomics that significantly alleviates the problem of ratio distortion caused by peptide co-fragmentation, as commonly observed in other reporter-ion based approaches, such as TMT and iTRA...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD021187 | Pride
Quantitative proteomics Data dependent acquisition Isobaric labeling Data-independent acquisition 
ProteomicsSMD-IPTL 4-plex yeast and BSA-yeast
Isobaric peptide termini labeling (IPTL) is an attractive protein quantification method, because it provides more accurate and reliable quantification information than traditional isobaric labelling methods (TMT, iTRAQ) by making use of the entire fragment ion series instead of only a single reporte...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-04-27 | PXD018589 | Pride
Smd-iptl 
ProteomicsA Collision-induced Dissociation Cleavable Isobaric Tag for Peptide Fragment Ion-based Quantification in Proteomics
Fragment ion-based proteome quantification methods quantify peptides based on unique peptide fragment ions avoiding the issue of ratio distortion that is commonly observed for reporter ion-based quantification approaches. Herein, we present a novel approach that relies on a collision-induced dissoci...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-08-17 | PXD018790 | Pride
Isotopic labelling Proteomics Cid cleavable tag Fragment ion-based quantification Isobaric labelling 
ProteomicsA rapid transcriptional opto-switch enables diatom acclimation to dynamic light
Diatoms outnumber other eukaryotic algae in the oceans, especially in coastal environments characterized by frequent fluctuations in light intensity. The mechanisms underlying their acclimation to high light stress are largely elusive. We identified an important light receptor gene responsible to hi...
ORGANISM(S): Chlamydomonas reinhardtii 
2024-08-10 | PXD050435 | Pride
Chlamydomonas reinhardtii 
ProteomicsA rapid transcriptional opto-switch enables diatom acclimation to dynamic light
Diatoms outnumber other eukaryotic algae in the oceans, especially in coastal environments characterized by frequent fluctuations in light intensity. The mechanisms underlying their acclimation to high light stress are largely elusive. We identified an important light receptor gene responsible to hi...
ORGANISM(S): Chlamydomonas reinhardtii 
2024-08-09 | PXD045344 | Pride
Algae High light stress 
ProteomicsA rapid transcriptional opto-switch enables diatom acclimation to dynamic light
Diatoms outnumber other eukaryotic algae in the oceans, especially in coastal environments characterized by frequent fluctuations in light intensity. The mechanisms underlying their acclimation to high light stress are largely elusive. We identified an important light receptor gene responsible to hi...
ORGANISM(S): Phaeodactylum tricornutum (strain CCAP 1055/1) 
2024-08-09 | PXD045342 | Pride
Algae High light stress 
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
ProteomicsMass-spectroscopic quantification of CHAC1-regulated protein cysteine S-glutathionylation
S-glutathionylation is an important post-translational modification of a cysteine residue of target protein. We applied a quantitative redox proteomics approach to identify the specific cysteine residues as targets of S-glutathionylation. Using this approach, we profiled CHAC1-associated changes in ...
ORGANISM(S): Mus Musculus 
2024-03-12 | PXD050569 |
ProteomicsA proximity labeling map of SARS-CoV-2 and human
The global epidemic caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in the infection of over 200 million people. To extend the knowledge of interactions between SARS-CoV-2 and humans, we systematically investigate the interactome of 29 viral protei...
ORGANISM(S): Homo Sapiens 
2022-01-06 | PXD022086 |
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