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ProteomicsOmics Reveal Far Reaching Effects of Verapamil Treatment in Subjects with Type 1 Diabetes
Proteomic data from recent onset T1D patients treated with verapamil where significant extension of the honeymoon phase was observed. Samples were depleted with MARS Hu-14 column, digested with trypsin, labeled with 11-plex TMT, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-09 | MSV000087598 | MassIVE
TranscriptomicsExpression data from BRAFV600E A375 melanoma cells treated with vehicle or vemurafenib
Vemurafenib is a BRAF inhibitor with specificity for the most common BRAF mutant encountered in melanomas (BRAFV600E). Vemurafenib suppresses the proliferation of BRAF mutant human melanoma cells by suppressing downstream activation of the MEK/ERK mitogen activated protein kinases. We used microarra...
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-42872 | biostudies-arrayexpress
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (DNA Methylation)
Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have been reported before and may be responsible for aging-induced changes in gene expression, although a c...
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49064 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (before and after in vitro differentiation)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60828 | biostudies-arrayexpress
Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
TranscriptomicsMicroarray expression profiling of male and female bone marrow derived macrophages from wild type and lysMCre/Irf2bp2flox mice
Interferon regulatory factor 2 binding protein 2 (Irf2bp2) is a corepressor of Irf2 that suppresses inflammatory gene expression and promotes the M2 macrophage phenotype in bone marrow derived macrophages (BMDM). Loss of Irf2bp2 in male macrophages promotes an inflammatory phenotype. Here, we compar...
ORGANISM(S): Mus musculus domesticus 
2024-09-01 | E-MTAB-14166 | biostudies-arrayexpress
UnknownEfficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial.
Not available
S-EPMC8813065 | biostudies-literature
UnknownEarly Convalescent Plasma for High-Risk Outpatients with Covid-19.
Not available
S-EPMC8385553 | biostudies-literature
UnknownEfficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial.
Not available
S-EPMC8409066 | biostudies-literature
UnknownRenin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials.
Not available
S-EPMC10091180 | biostudies-literature
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