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ProteomicsMembrane prewetting by condensates promotes tight junction belt formation
Time-resolve proximity proteomics of tight junction. To understand how the tight junction belt is assembled and positioned, we combined APEX2 proximity proteomics of the main junctional scaffold protein ZO-1 with a calcium switch tissue formation assay.This combination allowed us to synchronize the ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-05-22 | PXD052221 | Pride
Canis lupus Tight junction Tmt Apex2 Mdck-ii 
TranscriptomicsLoss of tight junction integrity induces loss of epithelial phenotype: case of Claudin11 knock out in testis.
Epithelium barrier integrity is assumed at least in part by the presence of junctions between cells. Tight-junction formation may be necessary for Sertoli cells to cease dividing and to support germ cell development. Microarray analysis of P20 Cldn11 +/- and Cldn11-/- testes confirmed the impact od ...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-15492 | biostudies-arrayexpress
UnknownNewly synthesized claudins but not occludin are added to the basal side of the tight junction.
Not available
S-EPMC6724697 | biostudies-literature
UnknownA complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.
Not available
S-EPMC4571337 | biostudies-literature
ProteomicsMapping the anti-cancer activity of alpha-connexin carboxyl-terminal (aCT1) peptide in resistant HER2+ breast cancer
Connexin 43 (Cx43) is a protein encoded by the GJA1 gene and is a component of cell membrane structures called gap junctions, which facilitate intercellular communication. Prior evidence indicates that elevated GJA1 expression in the HER2-positive (HER2+) subtype of breast cancer is associated with ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-01 | MSV000093550 | MassIVE
TranscriptomicsThe Tight Junction Protein Claudin-2 Controls Mucosal Permeability, Immune Tolerance and Colitis in Mice
The mucosal epithelium plays a key role in regulating immune homeostasis. Dysregulation of epithelial barrier function is associated with mucosal inflammation. Expression of claudin-2, a pore-forming tight junction protein, is highly upregulated during inflammatory bowel disease (IBD) and, due to it...
ORGANISM(S): Mus musculus 
2013-09-15 | E-GEOD-46006 | biostudies-arrayexpress
TranscriptomicsExpression data for human epithelium from subjects with atopic dermatitis, psoriasis and nonatopic controls
The expression and function of tight junction genes, in particular claudin-1, was studied in order to further understanding of the biology underlying atopic dermatitis. Gene expression profiling was performed on total RNA from nonlesional epidermal samples from 5 subjects with atopic dermatitis, 4 s...
ORGANISM(S): Homo sapiens 
2011-01-29 | E-GEOD-26952 | biostudies-arrayexpress
GenomicsClostridioides difficile toxins deregulate tight junction proteins.
Clostridioides difficile toxins deregulate tight junction proteins.
PRJNA973611 | ENA
ProteomicsDiscovery of mammalian tissue-derived peptides that induce tight junction formation
Tight junctions (TJs) are cell-cell adhesion structures that function as barriers between epithelial cells to avoid dehydration, regulate ion permeability and prevent invasion of bacteria and viruses. Disruption of TJs is causative of various inflammatory diseases including inflammatory bowel diseas...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2020-06-28 | PXD014424 | JPOST Repository
UnknownMultiple claudin-claudin <i>cis</i> interfaces are required for tight junction strand formation and inherent flexibility.
Not available
S-EPMC6123731 | biostudies-literature
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