Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Loss of tight junction integrity induces loss of epithelial phenotype: case of Claudin11 knock out in testis.

ABSTRACT: Epithelium barrier integrity is assumed at least in part by the presence of junctions between cells. Tight-junction formation may be necessary for Sertoli cells to cease dividing and to support germ cell development. Microarray analysis of P20 Cldn11 +/- and Cldn11-/- testes confirmed the impact od Cldn11 deficiency on cell cytoskeleton and junction-related genes. Keywords: transcriptomic analysis Two-condition experiment: P20 Cldn11 +/- vs. P20 Cldn11 -/- testes. A pool of RNA from P20 Cldn11 +/- group was used as the reference group. Each P20 Cldn11 -/- was compared to reference group. Three biological replicates were processed in dye swap.

ORGANISM(S): Mus musculus

SUBMITTER: emmanuelle meugnier 

PROVIDER: E-GEOD-15492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis.

Mazaud-Guittot S S   Meugnier E E   Pesenti S S   Wu X X   Vidal H H   Gow A A   Le Magueresse-Battistoni B B  

Biology of reproduction 20090909 1

Tissue integrity relies on barriers formed between epithelial cells. In the testis, the barrier is formed at the initiation of puberty by a tight junction complex between adjacent Sertoli cells, thereby defining an adluminal compartment where meiosis and spermiogenesis occur. Claudin 11 is an obligatory protein for tight junction formation and barrier integrity in the testis. It is expressed by Sertoli cells, and spermatogenesis does not proceed beyond meiosis in its absence, resulting in male s  ...[more]

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