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TranscriptomicsTranscription profiling of mouse VE-cadherin null cell line vs contrik
In order to identify genes regulated by VE-cadherin expression, we compared a mouse VE-cadherin null cell line (VEC null) with the same line reconstituted with VE-cadherin wild type cDNA (VEC positive). The morphological and functional properties of these cell lines were described previously [Lampug...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11674 | biostudies-arrayexpress
ProteomicsIP-MS identification of protein interaction for Na (+), K (+)-ATPase beta1 subunit
This project aims to identify proteins that may interact with the sodium potassium pump (ATPase) beta1 subunit in the human lung.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-02 | MSV000084881 | MassIVE
TranscriptomicsLoss of tight junction integrity induces loss of epithelial phenotype: case of Claudin11 knock out in testis.
Epithelium barrier integrity is assumed at least in part by the presence of junctions between cells. Tight-junction formation may be necessary for Sertoli cells to cease dividing and to support germ cell development. Microarray analysis of P20 Cldn11 +/- and Cldn11-/- testes confirmed the impact od ...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-15492 | biostudies-arrayexpress
TranscriptomicsA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
In a genome-wide screen of human cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reco...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
UnknownEpidermal tight junctions in health and disease.
Not available
S-EPMC4372028 | biostudies-literature
ProteomicsDysregulation of Cell-Cell Interaction in Brain Arteriovenous Malformations: A Quantitative Proteomics Study
Object. Detailed and exact mechanisms underlying brain arteriovenous malformations (bAVM) are still confusing in clinic. Understanding the quantitative changes of proteins and signaling pathways would provide useful information for clinicians to understand the formation and development of bAVM and t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080716 | MassIVE
GenomicsInflammation of gill epithelia in fish causes increased permeation of polar organic chemicals from OSPW via disruption of tight junctions
Inflammation of gill epithelia in fish causes increased permeation of polar organic chemicals from OSPW via disruption of tight junctions
PRJNA758417 | ENA
GenomicsLoss of tight junctions disrupts gastrulation patterning and increases differentiation towards the germ cell lineage in human pluripotent stem cells
Loss of tight junctions disrupts gastrulation patterning and increases differentiation towards the germ cell lineage in human pluripotent stem cells
PRJNA883000 | ENA
ProteomicsEpigenetic silencing of tight junction protein CLDN10B in renal cancer including post-transplantation RCC and its endogenous reactivation by CRISPR results in cell growth suppression.
Background The kidney's tubular system, composed of nephrons and collecting ducts, relies on cellular planar polarity and tight junctions to maintain structure and function. Disruptions in this polarity contribute to diseases like cystic kidney disease and cancer. Tight junctions, such as those form...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-01 | MSV000095998 | MassIVE
UnknownProtein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions.
Not available
S-EPMC3408004 | biostudies-literature
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