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TranscriptomicsGastric cancers of Western European and African patients
Gastric cancer is the second most common cause of cancer death worldwide, but incidence and mortality rates show large variations across different countries. Variation in risk factors between different populations, including environmental and host factors influencing gastric cancer risk, have been r...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-22789 | biostudies-arrayexpress
TranscriptomicsLosses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome
Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-26389 | biostudies-arrayexpress
TranscriptomicsRunx1 is a tumor suppressor gene in the mouse gastrointestinal tract
The Runx1 transcription factor plays an important role in tissue homeostasis through its effects on stem/progenitor cell populations and differentiation. The effect of Runx1 on epithelial differentiation of the secretory cell lineage of the colon was recently demonstrated. This study aimed to examin...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-34292 | biostudies-arrayexpress
TranscriptomicsChromosomal abberations and transcriptional characteristics linked to the pathogenesis of diffuse large b-cell lymphomas
We superimposed array comparative genomic hybridization (aCGH) data onto existing expression array profiles (GSE3892) to sift out the pivotal genes underlying the pathogenesis of a well defined series of diffuse large B-cell lymphomas (DLBCL). 280 gained and over-expressed genes were identified, loc...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-5138 | biostudies-arrayexpress
TranscriptomicsLack of microRNA-101 causes E-cadherin expression and function deregulation through EZH2 up-regulation in gastric cancer
Background & Aims: E-cadherin expression disruption is commonly observed in epithelial cancers and metastasis. Such event is also recognized as a crucial step in gastric cancer (GC) initiation and progression. As aberrant expression of microRNAs often perturb the normal expression and function of pi...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33743 | biostudies-arrayexpress
TranscriptomicsArray comparative genomic hybridization in sporadic and coeliac disease-related small bowel adenocarcinomas
Background: The molecular pathogenesis of small intestinal adenocarcinomas (SBA) is not well understood. Defining its molecular pathogenesis may lead us to better clinical interventions. Aim: to identify the molecular changes characteristic of SBA. Methods: Forty-eight SBA (thirty-three non coelia...
ORGANISM(S): Homo sapiens 
2009-10-07 | E-GEOD-15470 | biostudies-arrayexpress
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