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TranscriptomicsStructurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. These multi-ring chemicals differentially activate the Aryl Hydrocarbon Receptor (AHR) in a structurally-dependent manner, and induce toxicity via both AHR-dependent...
ORGANISM(S): Danio rerio 
2013-05-15 | E-GEOD-44130 | biostudies-arrayexpress
TranscriptomicsDiet-Induced Obesity Exacerbates Inflammatory and Oxidative Stress Responses in Mice Exposed to Cigarette Smoke
To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-38093 | biostudies-arrayexpress
TranscriptomicsImpaired Transcriptional Response of the Murine Heart To Cigarette Smoke in the Setting of High Fat Diet and Obesity
To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure...
ORGANISM(S): Mus musculus 
2013-05-17 | E-GEOD-47022 | biostudies-arrayexpress
TranscriptomicsDiet-Induced Obesity Reprograms the Inflammatory Response of the Murine Lung to Inhaled Endotoxin
To identify key biological pathways that define susceptibility factors for pulmonary infection during obesity, diet-induced obese (DIO) and regular weight (RW) C57BL/6 mice were exposed to 0.5 M-BM-5g/L inhaled lipopolysaccharide (LPS) for 1 hr/d for 4 days over a period of 2 weeks. Transcriptional ...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-38092 | biostudies-arrayexpress
MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
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