Tim-4 - OmicsDI

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1-(4-Aminosulphonylphenyl)-5-(2,4-difluorophenyl)-4,5-dihydro-3-trifluoromethyl-1H-pyrazole (1)
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[(3S)-1-Azabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2-(4-iodophenyl)-2-phenylacetate (1)

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Lab affiliation

Department of Neurobiology, Northwestern University (1)
Proteomics Platform cic bioGUNE Bizkaia Tech. Park Build. 800 Derio 48160 Spain (1)
Department of Functional Sciences, Faculty of Veterinary Medicine, Pharmacology and Toxicology, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000 Liège 1 (Sart Tilman), Belgium (1)
Department of Chemistry, Yale University, New Haven, CT 06511, USA (1)
Kevin Pagel: Institute of Chemistry and Biochemistry, Freie Universität Berlin, Altensteinstraße 23A, 14195 Berlin, Germany. Fritz Haber Institute of the Max Planck Society, Faradayweg 4‑6, 14195 Berlin, Germany. Philipp Mertins (Philipp.mertins@mdc-berlin.de) : Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. Berlin Institute of Health (BIH), Berlin, Germany. (1)
Max Planck Institute of Biochemistry, Department of Cellular Biochemsitry (1)
University of Bristol (1)
Institute of Pharmacology and Structural Biology, CNRS, Toulouse (1)

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effects of depeltion of Tim-4 on gene expression in Peritoneal macrophages (PEMs)

PRJNA1146889 | ENA

Identification of Tim-4 Binding Proteins in Peritoneal Macrophages

T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is known to suppress macrophage inflammatory responses in various diseases, but its role and underlying mechanism in peritoneal macrophage (PEMs) with LPS stimulation are unknown. PEMs were isolated from Tim-4fl/fl mice and LysM-Cre; Tim-4f...

ORGANISM(S): Mus Musculus

PXD066149 |

RNA-seq analysis of wild type and Tim-4 KO mice primary peritoneal macrophages

PRJNA885039 | ENA

Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [RNA-Seq]

PRJNA728599 | ENA

Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis.

Not available

S-EPMC7408610 | biostudies-literature

Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [RNA-Seq]

Here we report RNA sequencing data from sorted Tim-4low vs Tim-4high macrophages in steady-state (no tumor) mice and also MC38-LG-tumor-bearing animals that were treated with isotype or anti-Tim-4 antibody.

ORGANISM(S): Mus musculus

2021-05-12 | GSE174151 | GEO

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Not available

S-EPMC2757006 | biostudies-literature

Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [scRNA-Seq]

PRJNA728907 | ENA

RNA-seq analysis of wild type and Tim-4 KO mice primary peritoneal macrophages

To investigate transcriptomic changes upon depletion of Tim-4 in macrophages

ORGANISM(S): Mus musculus

2022-11-30 | GSE214346 | GEO

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.