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MetabolomicsTime-resolved decoding of metabolic signatures of in vitro growth of the hemibiotrophic pathogen Colletotrichum sublineolum
Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotric...
2022-05-30 | MTBLS735 | MetaboLights
ProteomicsTime-resolved combined analysis of transcriptome and proteome of the pathogenicity-activated plant pathogen Xanthomonas oryzae pv. oryzae
Xanthomonas oryzae pv. oryzae (Xoo) is a rice pathogen causing bacterial blight, which outbreaks in most rice cultivating countries and reduces yield up to 50% due to no effective pesticide. Urgent responses of Xoo upon the initial contacts with rice at infection site are essential for pathogenesis....
ORGANISM(S): Xanthomonas oryzae pv. oryzae KACC 10331 
2021-09-09 | PXD020135 | Pride
Transcriptome Time-resolved gene expression Xoo–rice interactions Pathogenicity Proteome Xanthomonas oryzae pv. oryzae 
TranscriptomicsTime resolved ribosome profiling study of oxygen and glucose deprivation of rat pheochromocytoma cells
Oxygen and glucose metabolism plays a pivotal role in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) occurs during ischemia and stroke, resulting in extensive tissue injury and cell death. We applied time-resolved ribosome profiling technique to assess earl...
ORGANISM(S): Rattus norvegicus 
2015-04-10 | E-GEOD-60752 | biostudies-arrayexpress
ProteomicsA time-resolved multi-omics atlas of Acanthamoeba castellanii encystment
Encystment is a common response of most protists to stress. Although some signaling pathways regulating this process were reported, our knowledge remains limited. Here, we mapped the molecular changes occurring in the amoeba Acanthamoeba castellanii during the early steps of encystment. De novo anal...
ORGANISM(S): Acanthamoeba castellanii str. Neff 
2022-07-12 | PXD031788 | Pride
Acanthamoeba castellanii Encystment Time-resolved molecular atlas 
ProteomicsDynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa
Post-transcriptional tRNA modifications dynamically regulate translational capacity, yet whether the tRNA epitranscriptome is temporally coordinated with gene expression programs during bacterial growth remains unknown. Here, we combine time-resolved nanopore tRNA sequencing, LC-MS/MS modification p...
ORGANISM(S): Pseudomonas aeruginosa Bacteria 
2026-10-03 | PXD077153 | Pride
Trna modification Pseudomonas aeruginosa 
UnknownAnalysis of time-resolved gene expression measurements across individuals.
Not available
S-EPMC3857324 | biostudies-literature
GenomicsTime-resolved gene expression analysis of the astrocyte-derived cell line 1321N1 treated with cadmium, mercury and arsenic.
Time-resolved gene expression analysis of the astrocyte-derived cell line 1321N1 treated with cadmium, mercury and arsenic.
PRJNA1182761 | ENA
ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000095981 | MassIVE
TranscriptomicsGrowing pains: natural stress response during growth of B. subtilis (high density time-resolved transcriptome analysis)
We have determined the time-resolved transcriptome of the model gram-positive organism B. subtilis during growth on rich medium. DNA microarrays were used to monitor gene transcription in 10-minute intervals at 40 consecutive timepoints. From the growth curve and a PCA analysis of all gene expressio...
ORGANISM(S): Bacillus subtilis 
2011-10-31 | E-GEOD-19831 | biostudies-arrayexpress
ProteomicsTime-Resolved Analysis of Protein-Protein Ensembles using a Destabilizing Domain (TRAPPED) to resolve dynamic interactions of SARS-CoV-2 nsp15
Cellular protein-protein interactions are dynamic and can change over time. Current interactomics methods capture steady-state information but lack the ability to differentiate when the interactions occur. This study developed a post-translational method for synchronizing protein accumulation that a...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD063935 | Pride
Dihydrofolate reductase Proteomics Affinity purification-mass spectrometry Interactomics Destabilizing domain Virus-host protein interactions 
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