Sort   by:  
 Page size 
TranscriptomicsTHP1 derived macrophage and foam cell gene expression in presence and absence of T0901317 and RNAi analyses of LXRa/b
To assess the LXRa dependent regulatory pathways in macrophages and foam cells we treated our two, THP1 derived native and LXR-knockdown cell models either with T0901317 or vehicle control (DMSO).
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1106 | biostudies-arrayexpress
GenomicsRegulation of the KEAP1/NRF2 oxidative stress response pathway by BRD4 in prostate and colorectal cancer
To identify genes regulated by BRD4 and to provide insight into new mechanisms de-regulated by BRD4, such as the response to oxidative stress, we integrated BRD4-binding regions with BRD4 gene expression data. For this analysis we performed BRD4 chromatin immunoprecipitation experiments and BRD4 kn...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-50491 | biostudies-arrayexpress
TranscriptomicsThe bromodomain protein BRD4 regulates splicing during heat shock
During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of EpiSCs undergoing differentiation induced by EB formation
To examine global gene expression changes during differentiation of epiblast stem cells (EpiSCs) induced by embryoid body (EB) formation, we performed RNA-seq analysis.
ORGANISM(S): Mus musculus 
2018-06-01 | E-MTAB-5343 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Esrrb, Nanog, Oct4, and Sox2 in EpiSCs undergoing reprogramming
To investigate the molecular mechanisms underlying the reprogramming of epiblast stem cells (EpiSCs) into embryonic stem cells (ESCs) induced by Esrrb, we performed ChIP-seq analysis of Esrrb, Nanog, Oct4, and Sox2 in Tet-on Esrrb EpiSCs after treatment with doxycycline (Dox).
ORGANISM(S): Mus musculus 
2018-06-01 | E-MTAB-5342 | biostudies-arrayexpress
Genomics"Targeted High Throughput Sequencing in Clinical Cancer Settings: Formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity"
"Background: Massively parallel sequencing technologies have brought an enormous increase in sequencing throughput. However, these technologies need to be further improved with regard to reproducibility and applicability to clinical samples and settings. Methods: Using identification of genetic var...
EGAS00001000136 | EGA
TranscriptomicsHigh-throughput sequencing of matched colorectal normal, tumor and metastasis tissues and proof-of principal bioinformatics modeling of therapeutic consequences of miRNA applications
MiRNAs are discussed as diagnostic and therapeutic molecules. However, effective miRNA drug treatments with miRNAs are so far hampered by the complexity of the miRNA networks. To identify potential miRNA drugs in colorectal cancer, we profiled miRNA and mRNA expression in matching normal, tumor and ...
ORGANISM(S): Homo sapiens 
2013-09-18 | E-GEOD-46622 | biostudies-arrayexpress
GenomicsDAT_CancerMethodsPaper_SNVTumorFoci - samples
"Single nucleotide variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000035 | EGA
GenomicsDAT_CancerMethodsPaper_CNVTumorFoci - samples
"Copy number variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000036 | EGA
GenomicsDAT_CancerMethodsPaper_FFPE - samples
"SNV detection from formalin fixed paraffin embedded (FFPE) samples"
EGAD00001000033 | EGA
Sort   by:  
 Page size