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TranscriptomicsA transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype (resting muscle after endurance training)
The molecular pathways which are activated and contribute to physiological remodeling of skeletal muscle in response to endurance exercise have not been fully characterized. We previously reported that ~800 gene transcripts are regulated following 6 weeks of supervised endurance training in young se...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35659 | biostudies-arrayexpress
TranscriptomicsStockholm dataset for ageing prototype diagnostic
Muscle biopsy samples from healthy male subjects at the baseline belonging to either <29y or >59y age range. These samples were used to design a prototype of multi-tissue molecular diagnostic of healthy physiological age. Resting skeletal muscle sample after an overnight fast. related to GSE18583
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-59880 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Exiqon)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to in...
ORGANISM(S): Mus musculus 
2011-05-31 | E-GEOD-27912 | biostudies-arrayexpress
TranscriptomicsImpact of resistance exercise on human skeletal muscle gene expression - ageing
The aim of this work was to produce a reproducible molecular signature of human muscle responses to resistance training and examine how such a profile relates to new and established exercise adaptation gene networks. Subjects were recruited from an age range of 18 to 75 y. Before beginning the study...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-47881 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Affymetrix)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to in...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-27949 | biostudies-arrayexpress
TranscriptomicsmRNA profiling in rectus abdominis muscle from patients with upper GI cancer
Rectus abdominis muscle biopsies were obtained from 65 upper gastrointestinal (UGI) cancer patients during open surgery and RNA profiling was performed on a subset of this cohort (n=21) using the Affymetrix U133+2 platform with the aim of identifying biomarkers of cancer related muscle wasting. N = ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-18832 | biostudies-arrayexpress
TranscriptomicsGene expression in skeletal muscle of cancer patients before and after potentially curative surgery
The mechanisms underlying muscle wasting in cancer patients remain poorly understood, and consequently there remains an unmet clinical need for new biomarkers and treatment strategies. Microarrays were used to examine the transcriptome in single biopsies from healthy controls (n=6) and in paired bio...
ORGANISM(S): Homo sapiens 
2012-04-13 | E-GEOD-34111 | biostudies-arrayexpress
TranscriptomicsThe Heritage (HEalth, RIsk factors, exercise Training And GEnetics) family study
The overall objective of the heritage project is to study the role of the genotype in cardiovascular,metabolic and hormonal responses to aerobic exercise training and the contribution of regular exercise to changes in several cardiovascular disease and diabetes risk factors. The study cohort in this...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-47874 | biostudies-arrayexpress
TranscriptomicsBaseline skeletal muscle gene expression
Muscle biopsy samples were obtained from two groups of male subjects prior to endurance training. The samples were used to predict training responses. Baseline gene expression involving 30 probe sets was able to classify subjects into high and low responders. Resting skeletal muscle sample after an ...
ORGANISM(S): Homo sapiens 
2010-02-03 | E-GEOD-18583 | biostudies-arrayexpress
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