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MetabolomicsCeramide Disrupts TM9SF2-PGK1 Axis to Redirect PD-L1 Trafficking and Enhance Antitumor Immunity

The PD-1/PD-L1 axis represents a cornerstone of cancer immunotherapy, yet the dynamic shuttling of PD-L1 between endosomal recycling and lysosomal degradation routes limits durable responses. Using a CRISPR screen targeting glycosphingolipid metabolism, we identify TM9SF2 as a key regulator of PD...

2026-02-05 | MTBLS13838 | MetaboLights
UnknownEndophytic l-asparaginase-producing fungi from plants associated with anticancer properties.
Not available
S-EPMC4642164 | biostudies-literature
UnknownGC-HRTOF-MS dataset of metabolites extracted from sorghum and ting (a fermented product) produced using two strains of Lactobacillus fermentum (singly and in combination).
Not available
S-EPMC8131565 | biostudies-literature
UnknownFrequent gene flow blurred taxonomic boundaries of sections in Lilium L. (Liliaceae).
Not available
S-EPMC5571923 | biostudies-literature
TranscriptomicsLysine catabolic pathways in P. aeruginosa
Among multiple interconnected pathways for L-Lysine (L-Lys) catabolism in pseudomonads, Pseudomonas aeruginosa PAO1 employed the decarboxylase and the transaminase pathways. However, up till now several genes involved in the operation and regulation of these pathways were still missing. Transcriptom...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2015-12-09 | E-GEOD-75502 | biostudies-arrayexpress
ProteomicsAnalysis of protein expression changes in patients with prediabetes using high-throughput proteomics
Objective: This study aimed to explore the mechanisms of early-onset T2DM by analyzing proteomic changes at different stages of glucose metabolism. Methods: A total of 40 individuals undergoing routine physical health examinations between December 2016 and April 2017 were enrolled. Subjects were di...
ORGANISM(S): Homo Sapiens 
2022-10-19 | PXD035367 |
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa PAO1 agmatine and putrescine catabolism
Polyamines (putrescine, spermidine, and spermine) are major organic polycations essential for a wide spectrum of cellular processes. The cells require mechanisms to maintain homeostasis of intracellular polyamines to prevent otherwise severe adverse effects. We performed a detailed transcriptome pro...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-16 | E-GEOD-9926 | biostudies-arrayexpress
UnknownLong-Term Correction of Nasolabial Folds Using Poly-L-Lactic Acid Microspheres: A Multicenter, Double-Blinded, Randomized Trial.
Not available
S-EPMC12903950 | biostudies-literature
ProteomicsPotential role of lysine acetylation in brown film formation and post-ripening of Lentinula edodes mycelium
Lentinula edodes is one of the most widely cultivated edible mushrooms in the world. When cultivated in sawdust, the surface mycelium of L. edodes needs a long post-ripening stage wherein it forms a brown film (BF) by secreting and accumulating pigments. BF formation is critical for the high quality...
ORGANISM(S): Lentinula Edodes 
2023-06-08 | PXD042811 |
UnknownSodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy.
Not available
S-EPMC3682891 | biostudies-literature
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