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MetabolomicsDetermination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets
Spatial metabolomics using mass spectrometry imaging (MSI) is a powerful tool to map hundreds to thousands of metabolites in biological systems. One major challenge in MSI is the annotation of m/z values, which is substantially complicated by background ions introduced throughout the c...
2021-06-15 | MTBLS954 | MetaboLights
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
MetabolomicsSpatial metabolomics of in situ, host-microbe interactions (On-tissue MALDI imaging MS/MS assay)
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defense molecules and chemical interactions in natural communities. Most current techniques are unable to spatially link the genotype and metabolic phenotype of microorganisms in situ at a ...
2019-11-15 | MTBLS805 | MetaboLights
GenomicsDelivery of a tissue derived extracellular matrix gel improves recovery following both acute and chronic disuse muscle injuries.
Delivery of a tissue derived extracellular matrix gel improves recovery following both acute and chronic disuse muscle injuries.
PRJNA910573 | ENA
TranscriptomicsKnockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage
Comparative analysis of gene expression in bone marrow-derived macrophages (BMDM) from trsp knockout mice (Trspfl/fl-LysM-Cre+/-) and Control (Trspfl/fl-LysM-Cre-/-) mice. Selenium, a micronutrient whose deficiency in the diet causes immune dysfunction and inflammatory disorders, exerts its physio...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-15610 | biostudies-arrayexpress
TranscriptomicsTissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial
The objectives of this study were to measure effects of an aspirin intervention on gene expression in normal colonic epithelial and stromal tissue in healthy humans and to determine whether response differed by UGT1A6*2 genotype. We also sought to characterize gene expression differences within colo...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-71571 | biostudies-arrayexpress
ProteomicsGel based extracellular matrix proteome of jute
Extracellular matrix (ECM) is the first line of defense which is an inimitable organelle that perceives biotic and abiotic stresses and reprograms biological processes of host. It also activates innate immune responses in temporal and spatial manner and acts as physical scaffold that prevents the en...
ORGANISM(S): Corchorus olitorius 
2024-05-21 | PXD046939 | Pride
1-de sds page Mass spectrometry Jute Extracellular matrix 
TranscriptomicsDelivery of a tissue derived extracellular matrix gel improves recovery following both acute and chronic disuse muscle injuries.
To evaluate decellularized skeletal muscle extracellular matrix hydrogel effectiveness in treating disuse atrophy using a mouse hindlimb suspension (HU) model. Male C57BL/6J mice were subjected to 5 days of hind limb unloading then received intramuscular matrix gel on the left TA. We then performed ...
ORGANISM(S): Mus musculus 
2023-01-02 | GSE220641 | GEO
TranscriptomicsMatrix Elasticity Does Not Affect Replicative Senescence or DNA Methylation Patterns of Mesenchymal Stem Cells [DNAm profiling]
Matrix elasticity influences differentiation of mesenchymal stem cells (MSCs) but it is unclear if these effects are only transient - while the cells reside on the substrate - or if they reflect persistent lineage commitment. In this study, MSCs were continuously culture-expanded in parallel either ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-55888 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ hematopoietic cells grown in suspension culture or in a collegen I matrix
CD34+ hematopoietic stem/progenitor cells (HSC) reside in the bone marrow in close vicinity to the endosteal bone surface, surrounded by osteoblasts, stromal cells and various extracellular matrix molecules. We utilized a bioartificial matrix containing fibrillar collagen I, the major matrix compone...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-3003 | biostudies-arrayexpress
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