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MetabolomicsTitanium dioxide in food induces sex- and microbiota-dependent metabolic disorders, and worsens high-fat diet outcomes
Ultra-processed food consumption has been linked to the rising global burden of metabolic diseases, but the specific contribution of additives commonly used in these products remains unclear. Given the bactericidal properties of the food-grade (fg) additive titanium dioxide (TiO2) and the key role o...
2026-05-19 | MTBLS14529 | MetaboLights
TranscriptomicsMaternal inhalation of surface-coated nano-sized titanium dioxide (UV-Titan): Effects in prenatally exposed offspring on hepatic DNA damage and gene expression
In the present study we investigate the effect of maternal pulmonary exposure to titanium dioxide (UV-Titan designed for use in the paint and lacquer industry) on prenatally exposed offspring. Time-mated mice (C57BL/6BomTac) were exposed by inhalation for 1 h/day to 42 mg UV-titan/m3 aerosolized pow...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-29067 | biostudies-arrayexpress
TranscriptomicsInvestigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of titanium dioxide nanoparticles
In this study, we investigated the safety of locally delivered titanium dioxide nanoaprticles at the level of gene expression in the retina. To figure out any definite dose-dependent effect, we injected titanium dioxide nanoparticles into the vitreous cavity of 8-week-old male C57BL/6 mice at the co...
ORGANISM(S): Mus musculus 
2013-07-20 | E-GEOD-49048 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of the Short Term Ingestion of Titanium Dioxide Nanofibers
Titanium dioxide nanofiber (TDNF) is widely used in the manufacture of various household products including cosmetics. As a result, there is a possibility of negative impact on human health. The goal of the present study is to investigate the short-term effects of titanium dioxide nanofiber ingestio...
ORGANISM(S): Rattus norvegicus 
2023-08-31 | E-MTAB-13260 | biostudies-arrayexpress
TranscriptomicsDietary titanium dioxide (E171) increases systemic ROS levels and alters the colon transcriptome – Evidence from a human dietary intervention study
This study provides critical insights into the adverse effects of titanium dioxide (E171) on human gastrointestinal health and its potential molecular mechanisms of action, marking a significant advancement in food toxicology. Through a human dietary intervention study involving 31 participants cons...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15089 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse inflammatory response to titanium dioxide particles exposure is enhanced during pregnancy
Rationale: Maternal immune responses can promote allergy development in offspring. Pilot data show that neonates of mother mice exposed during pregnancy to air pollution particles have increased allergic susceptibility. Objective: We investigated whether inflammatory response to titanium dioxide (Ti...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7475 | biostudies-arrayexpress
TranscriptomicsTitanium dioxide nanoparticles exposure
This project utilized oligonucleotide microarrays to examine gene expression patterns in adult male fathead minnows (Pimephales promelas) exposed to a common nanomaterial, titanium dioxide (TiO2, stearate-coated particles, MT-100TV®). We exposed adult male fathead minnows for 96 hr to three doses (...
ORGANISM(S): Pimephales promelas 
2010-12-22 | E-GEOD-17902 | biostudies-arrayexpress
TranscriptomicsInvestigation of titanium coated imprinted polystyrene surfaces
In this study the gene expression differences between two titanium surfaces produced at Maastricht University were investigated. These two surfaces were: flat titanium-coated polystyrene and a titanium-coated polystyrene surface imprinted with a pattern selected from an earlier screening study (Ti10...
ORGANISM(S): Homo sapiens 
2018-09-25 | E-MTAB-7212 | biostudies-arrayexpress
TranscriptomicsInvestigation of titanium discs produced by Straumann on human mesenchymal stromal cells
In this study the gene expression differences between three titanium surfaces produced by Straumann were investigated. These three surfaces were: flat pre-treated (Pt) titanium, sandblasted (S) titanium and sandblasted acid-etched (SLA) titanium. The SLA surface is known to boost the proliferation a...
ORGANISM(S): Homo sapiens 
2018-09-05 | E-MTAB-7217 | biostudies-arrayexpress
ProteomicsProteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model
Background: Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing will become a clinical problem and will affect the patient's qua...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-29 | PXD016135 | Pride
Ms-based proteomics Titanium implant Growth factors Bone healing 
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