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ProteomicsMS-based phosphosite mapping in TKUL protein from Leishmania mexicana
Here we use MS to analyse the in-vitro autophosphorylation sites of the purified dual-functional protein, TKUL, from Leishmania mexicana.
ORGANISM(S): Leishmania mexicana MHOM/GT/2001/U1103 
2025-09-24 | PXD056904 | Pride
Tkul Phosphorylation Kinase Ubiquitin ligase Leishmania mexicana 
ProteomicsA Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating protein kinase and ubiquitin ligase domains within a single protein. This module is widespread across unicellular eukaryotic lineages and particularly co...
ORGANISM(S): Leishmania mexicana 
2025-09-23 | PXD057190 | Pride
Ser/thr kinase Hydrogen-deuterium exchange mass spectrometry (hdx-ms) Enzyme regulation Tpr domain Ubiquitin ligase X-ray crystallography Phosphorylation Hect e3 Allostery Heat-shock protein 70 (hsp70) 
ProteomicsA Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating protein kinase and ubiquitin ligase domains within a single protein. This module is widespread across unicellular eukaryotic lineages and particularly co...
ORGANISM(S): Trypanosoma brucei 
2025-09-22 | PXD053520 | Pride
Lc-ms/ms 
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