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MetabolomicsTranscobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism

BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...

2024-05-28 | MTBLS9136 | MetaboLights
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
TranscriptomicsCross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects
The activation of TLR-MyD88 (Toll like receptor- Myeloid differentiation factor 88) signaling within T cells functions as a potent costimulatory signal that boosts antitumor and antiviral responses. However, the molecular mechanisms underlying the costimulatory processes are poorly understood. We co...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-79475 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine E10.5 TLR2+ CD11b+ embryonic phagocytes by comparative microarray analyses
The detection of Toll-like receptor 2 (TLR2) expression on E10.5 early embryonic phagocytes prompted us to determine the list of markers co-expressed with TLR2 in a cell-type specific manner. Thus, a comparative expression profiling of cDNAs between murine E10.5 TLR2+ CD11b+ embryonic cells and TLR2...
ORGANISM(S): Mus musculus 
2014-12-01 | E-MTAB-1537 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cell lines in response to Helicobacter pylori lipopolysaccharide shows Tribbles 3 - a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide
This SuperSeries is composed of the following subset Series: GSE25146: Changes in gene expression in AGS cells in response to Helicobacter pylori lipopolysaccharide GSE25147: Changes in gene expression in MKN45 cells in response to Helicobacter pylori lipopolysaccharide GSE25148: Changes in gene exp...
ORGANISM(S): Homo sapiens 
2011-01-12 | E-GEOD-25155 | biostudies-arrayexpress
TranscriptomicsTLR2/6 agonists and IFNgamma induce CXCL10 from melanoma
Clinical approaches to treat advanced melanoma include immune therapies, whose benefits depend on tumor-reactive T-cells to infiltrate metastases. However, most tumors lack significant immune infiltration prior to therapy, and some immune therapies are hindered by a persistent lack of immune cell in...
ORGANISM(S): Homo sapiens 
2015-11-22 | E-GEOD-64506 | biostudies-arrayexpress
TranscriptomicsHuman monocyte activation with NOD2L vs. TLR2/1L
human blood monocytes were isolated, activated and harvested at several timepoints In this study, we identified genes that were differentially expressed in human monocytes activated with eiter NOD2L and/or TLR2/1L. human blood monocytes were purified from healthy donors by Ficoll, Percoll and adhere...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-34156 | biostudies-arrayexpress
TranscriptomicsExpression data from proximal jejunum of WT vs. TLR2 KO mice after methotrexate (MTX) treatment
The role of innate immunity in modulating severity of chemotherapy-induced complications is so far unclear. The aim of this study was to determine how TLR2 may influence MTX-induced mucositis in the small intestine in mice. We used microarrays to assess gene expression profiles in proximal jejunum o...
ORGANISM(S): Mus musculus 
2015-01-24 | E-GEOD-56426 | biostudies-arrayexpress
TranscriptomicsGenome wide analysis of C57BL-6 mice and C57BL/6 TLR2-KO mice infected with Chinese strain (SC84) of Streptococcus suis
Streptococcus suis is an emerging zoonotic agent causing meningitis and septicemia. Outbreaks in humans in China with atypical cases of streptococcal toxic shock-like syndrome have been described to be caused by a clonal epidemic S. suis strain characterized as sequence type (ST) 7 by multilocus seq...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45862 | biostudies-arrayexpress
TranscriptomicsGenome wide analysis of C57BL/6 mice and C57BL/6 TLR2-KO mice infected with European strain (P1/7) of Streptococcus suis
Streptococcus suis is an emerging zoonotic agent causing meningitis and septicemia. Outbreaks in humans in China with atypical cases of streptococcal toxic shock-like syndrome have been described to be caused by a clonal epidemic S. suis strain characterized as sequence type (ST) 7 by multilocus seq...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45861 | biostudies-arrayexpress
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