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GenomicsNext Generation Sequencing Analyzes Transcriptome after TMEM126A overexpression and knockdown
Next Generation Sequencing Analyzes Transcriptome after TMEM126A overexpression and knockdown
PRJNA493103 | ENA
ProteomicsOptic Atrophy-associated TMEM126A is an assembly factor for the ND4-module of Mitochondrial Complex I
Mitochondrial disease is a debilitating condition with a diverse genetic aetiology. Here, we report that TMEM126A, a protein that is mutated in patients with autosomal recessive optic atrophy, participates directly in the assembly of mitochondrial complex I. Using a combination of genome editing, in...
ORGANISM(S): Homo sapiens (Human) 
2021-04-21 | PXD023136 | Pride
Assembly factor Complex i Tmem126a Mitochondria 
TranscriptomicsNext Generation Sequencing Analyzes Transcriptome after TMEM126A overexpression and knockdown
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to identify the differential expression genes after TMEM126A overexpression or knockdown. Methods:Total cell mRNA profiles of TMEM126A-knockdown MDA-MB-231 cells (sh-...
ORGANISM(S): Homo sapiens 
2018-09-26 | GSE120468 | GEO
UnknownNovel transmembrane protein 126A (TMEM126A) couples with CD137L reverse signals in myeloid cells.
Not available
S-EPMC3466360 | biostudies-literature
UnknownIdentification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.
Not available
S-EPMC10805001 | biostudies-literature
UnknownOptic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I.
Not available
S-EPMC8092609 | biostudies-literature
UnknownNovel likely pathogenic variants in TMEM126A identified in non-syndromic autosomal recessive optic atrophy: two case reports.
Not available
S-EPMC6454730 | biostudies-literature
UnknownTMEM126A, encoding a mitochondrial protein, is mutated in autosomal-recessive nonsyndromic optic atrophy.
Not available
S-EPMC2667974 | biostudies-literature
UnknownTMEM126A mutation in a Moroccan family with autosomal recessive optic atrophy.
Not available
S-EPMC3398502 | biostudies-literature
UnknownNDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate.
Not available
S-EPMC8076766 | biostudies-literature
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