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ProteomicsFinding TMEM55B interactors and ubiquitination sites
Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms. Here we find the interactors for TMEM55B and also checked ubiquitination o...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD043609 | Pride
Tmem55b ms 
ProteomicsFinding TMEM55B phoshporylation site
Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms. Here we find the interactors for TMEM55B and also checked ubiquitination o...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD046394 | Pride
Tmem55b ms 
ProteomicsStructural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
Inherited mutations in VPS35 and the kinase LRRK2 lead to hyperphosphorylation of Rab GTPases and promote the formation of phospho-Rab signalling complexes. A subset of RH2 domain-containing proteins from the RILP-homology family, including RILP, RILPL1, RILPL2, JIP3, and JIP4 are Rab effectors that...
ORGANISM(S): Homo sapiens (Human) 
2025-11-30 | PXD067414 | Pride
Lysosome Lrrk2 Tmem55b Parkinson's disease Structure 
GenomicsEffects of TMEM55B deficiency on hepatic gene expression of Western diet-fed male mice
Effects of TMEM55B deficiency on hepatic gene expression of Western diet-fed male mice
PRJNA1143546 | ENA
TranscriptomicsEffects of TMEM55B deficiency on hepatic gene expression of Western diet-fed male mice
Transmembrane protein 55B (TMEM55B) is a lysosomal protein that modulates lysosome position and function. We examined the impact of TMEM55B deficiency on mitochondrial function and the development of Metabolic Dysfunction Associated with Steatohepatitis (MASH). We found that several genes implicated...
ORGANISM(S): Mus musculus 
2026-01-14 | GSE273884 | GEO
UnknownTFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Not available
S-EPMC5691037 | biostudies-literature
ProteomicsParkinson’s VPS35[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
The Parkinson’s VPS35[D620N] mutation causes lysosome dysfunction enhancing LRRK2 kinase activity. We find the VPS35[D620N] mutation alters expression of ~350 lysosomal proteins and stimulates LRRK2 recruitment and phosphorylation of Rab proteins at the lysosome. This recruits the phosphoRab effecto...
ORGANISM(S): Homo sapiens (Human) 
2023-11-08 | PXD045671 | Pride
Parkinson's disease Lrrk2 Lysosome Proteomics 
UnknownTMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress.
Not available
S-EPMC10761734 | biostudies-literature
UnknownLoss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function.
Not available
S-EPMC12789068 | biostudies-literature
UnknownParkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Not available
S-EPMC10848721 | biostudies-literature
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