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ProteomicsTMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer
This dataset contains an evaluation of TMT-based multiplexed proteomics on the Orbitrap Astral mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-17 | MSV000096674 | MassIVE
ProteomicsTMT-based plasma proteomics in humans at high altitude
In the present study, TMT-based proteomics studies was performed to decipher plasma proteome alterations in humans exposed to high altitude for short- (7 days, HA-D7) and long-term (3 months, HA-D150) stay.
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028070 | Pride
Human Plasma Tmt lc-ms/ms 
UnknownOptimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer's disease biomarkers.
Not available
S-EPMC9107710 | biostudies-literature
ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-01-29 | MSV000084859 | MassIVE
ProteomicsSerum proteome profiling in canine chronic valve disease using TMT-based quantitative proteomics
Cardiovascular-related disorders (CVD) account for the highest mortality rates in the world, and affect the quality and the quantity of life of patients, creating an economic burden of prolonged therapeutic intervention. The aim of this study was to evaluate the serum protein profile of healthy and ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2020-05-26 | PXD017129 | Pride
Dog Tandem mass tag Chronic valve disease Serum proteomics 
ProteomicsDiscovery of biomarkers for amyotrophic lateral sclerosis from human cerebrospinal fluid using mass spectrometry-based proteomics
Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative diseases characterized by the relentless loss of upper and lower motor neurons, eventually leading to death. Critical to the mission of developing effective therapies for ALS is the discovery of biomarkers that can illuminate mecha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-22 | PXD038846 | Pride
Cerebrospinal fluid Proteomics Mass spectrometry Amyotrophic lateral sclerosis And biomarker 
UnknownEvaluation of phosphopeptide enrichment strategies for quantitative TMT analysis of complex network dynamics in cancer-associated cell signalling.
Not available
S-EPMC4398868 | biostudies-literature
UnknownPan-Cancer Proteomics Analysis to Identify Tumor-Enriched and Highly Expressed Cell Surface Antigens as Potential Targets for Cancer Therapeutics.
Not available
S-EPMC10494184 | biostudies-literature
ProteomicsA carrier-based quantitative proteomics method applied to biomarker discovery in pericardial fluid
Data-dependent liquid chromatography tandem mass spectrometry (LC-MS/MS) is challenged by the large concentration range of proteins in plasma and related fluids. We adapted the SCoPE method from single-cell proteomics to pericardial fluid, where a myocardial tissue carrier was used to aid protein qu...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD053450 | Pride
Carrier proteome Single-cell proteomics Biomarker discovery 
ProteomicsTMT-based quantitative proteomics analysis reveals the attenuated replication mechanism of Newcastle disease virus caused by nuclear localization signal mutation in viral matrix protein
Nuclear localization of cytoplasmic RNA virus proteins mediated by intrinsic nuclear localization signal (NLS) plays essential roles in successful virus replication. We previously reported that NLS mutation in the matrix (M) protein obviously attenuates the replication and pathogenicity of Newcastle...
ORGANISM(S): Cricetidae 
2020-05-22 | PXD018098 | Pride
Newcastle disease virus  matrix protein  nuclear localization signal  nucleocytoplasmic trafficking  tmt  quantitative proteomics 
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