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TranscriptomicsTNFR1 controls apoptosis and chronic liver disease in hepatocyte-specific IKKγ (Nemo) mice.
Death receptor-mediated hepatocyte apoptosis is implicated in a wide range of liver diseases including viral hepatitis, alcoholic hepatitis, ischemia/reperfusion injury, fulminant hepatic failure, cholestatic liver injury and cancer. Deletion of NF-ĸB essential modulator in hepatocytes (NemoΔhepa) c...
ORGANISM(S): Mus musculus 
2014-09-03 | E-GEOD-33161 | biostudies-arrayexpress
ProteomicsAnalysis of the TNFR1-SC from HOIP-proficient and -deficient A549 cells
This study aimed at determining which components of the TNFR1-SC are recruited in dependency of HOIP.
ORGANISM(S): Homo sapiens (Human) 
2018-09-25 | PXD008497 | Pride
Ap-ms Tnfr1-sc Hoip 
TranscriptomicsTNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP
The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable ...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-10103 | biostudies-arrayexpress
TranscriptomicsExpression data from TNF-stimulated mouse glomeruli
The specific contribution of the two TNF-receptors Tnfr1 and Tnfr2 to TNF-induced inflammation in the glomerulus is unknown. In mice, TNF exposure induces glomerular expression of inflammatory mediators like adhesion molecules and chemokines in vivo, and glomerular accumulation of leukocytes. To exa...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-43928 | biostudies-arrayexpress
GenomicsTranscriptome analysis of TNFR1-knockout mouse colon
Transcriptome analysis of TNFR1-knockout mouse colon
PRJNA422126 | ENA
TranscriptomicsThe effect of Tumor Necrosis Factor Receptor 1 (TNFR1) loss on gene expression in beta-catenin-deprive colon cancer cells
Human colon carcinoma cells SKCO1 were deprived of either beta-catenin alone or beta-catenin together with TNFR1 and changes in mRNA levels were examined before and after TNFR1 ablation SKCO1 cells were transfected with either beta-catenin-specific siRNA alone or beta-catenin-specific siRNA together...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-61961 | biostudies-arrayexpress
ModelsSherekar2023 - Modeling heterogeneity in TNFR1 signaling model
Tumor microenvironment contains abundant quantities of Tumor necrosis factor alpha (TNFα) secreted by a battery of immune cells. Signal flow through TNFα stimulated TNFR1 signaling, which is supposed to maintain a fine balance between survival and cell-death phenotypes, is often sacrificed in a dise...
2025-04-22 | MODEL2504180001 | BioModels
TranscriptomicsIdentification of genes regulated by the RANK IVVY motif in macrophages
Identification of genes regulated by RANK RVVY motif in macrophages by gene expression analysis of TNFR1-/-R2-/- BMMs expressing a chimeric receptor consisting of the external domain of mouse TNFR1 linked to the transmembrane and intracellular domain of mouse RANK (WT) and NFR1-/-R2-/- BMMs expressi...
ORGANISM(S): Mus musculus 
2011-08-19 | E-GEOD-17745 | biostudies-arrayexpress
GenomicsEffects of TNFR1 deletion in mice in early life
Effects of TNFR1 deletion in mice in early life
PRJNA655131 | ENA
GenomicsEffects of TNFR1 deletion on Il10-/- mouse colitis in early life
Effects of TNFR1 deletion on Il10-/- mouse colitis in early life
PRJNA650513 | ENA
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