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CD40 (also known as TNFRSF5) is a critical transmembrane molecule expressed on B cells and on myeloid cells including DCs. In B cells, CD40 engagement by its ligand CD40L (CD154) is essential to promote immunoglobulin class switching, memory differentiation, and germinal center formation. Using affi...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD042695 | Pride
The CD40-CD40L dyad seems to play a prominent role fostering the immune-inflammatory response triggered by endothelial cell (EC)-T cell interaction. To comprehensively delineate the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knock-down with comparative genome-wide...
ORGANISM(S): Homo sapiens 
Evaluation of TRAP-sequencing by comparing transcriptomes and translatomes of different organs and distinct cell populations. E14.5 brain and kidney transcriptome and translatome profiling of organs or distinct cell populations from these organs was performed using the Illumina TruSeq RNA technology...
ORGANISM(S): Mus musculus 
Natural antibodies, which arise without known immune exposure, have been described that specifically recognize cells dying from apoptosis but their role in innate immunity remains poorly understood. Herein, we show that the immune response to neo-antigenic determinants on apoptotic thymocytes is dom...
ORGANISM(S): Mus musculus 
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