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TranscriptomicsExpression data from CD44loCD8+ T cells of sanroque versus wild-type mice
We used microarrays to detect the primary changes caused by the 'san' mutation in Roquin gene by comparing the gene expression profiles of naive (CD44lo) CD8+ T cell population. Sorted CD44loCD8+ T cells of age-matched sanroque (Roquinsan/san) and wild-type (Roquin+/+) mice in C57BL/6 background wer...
ORGANISM(S): Mus musculus 
2012-04-16 | E-GEOD-37319 | biostudies-arrayexpress
TranscriptomicsDNA methylation and expression profiling study for prostate cancer
Microarray-based DNA methylation and gene expression profiling was carried out using a panel of prostate cancer cell lines (LNCaP-FGC, DU-145, and PC-3) and the control normal prostate RWPE1 cell line. The identification of prostate cancer-specific methylation markers was based on the following crit...
ORGANISM(S): Homo sapiens 
2011-07-24 | E-GEOD-23388 | biostudies-arrayexpress
TranscriptomicsEffects of MYCN knockdwon on miRNA expression in neuroblastoma cells
Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN To identify MYCN-associated miRNAs, we carried out a small RNA-seq on MYCN knockdown in SK-N-BE(2)-C cells to profile the miRNA expression.
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-72721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells lines following DAC and ATRA treatment
Following treatment with the de-methylating agent 5-aza-deoxycytidine (DAC), the gene expression profiles of neuroblastoma cell lines Kelly, SK-N-AS and NGP were analysed in order to examine the relationship between transcriptional re-activation and promoter region DNA methylation.
In addition, t...
ORGANISM(S): Homo sapiens 
2010-11-03 | E-MEXP-2557 | biostudies-arrayexpress
TranscriptomicsLow-power photodynamic therapy induces survival signaling in cultured hilar cholangiocarcinoma cells
Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizerreplete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and inducti...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-68292 | biostudies-arrayexpress
TranscriptomicsmiR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (mRNA)
MicroRNA (miRNA) expression profiling identified miR-638 as one of the most significantly overexpressed miRNAs in metastatic lesions compared with primary melanomas. miR-638 enhanced the tumourigenic properties of melanoma cells in vitro and lung colonization in vivo. mRNA expression profiling of mi...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-54493 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human neuroblastoma cells treated with microRNAs 10a and 10b
Effect of microRNAs 10a and 10b on gene expression in neuroblastoma SK-N-BE cells
ORGANISM(S): Homo sapiens 
2010-12-17 | E-MEXP-2718 | biostudies-arrayexpress
TranscriptomicsGene expression profile of YAP1, TEAD1 and KLF5 in hepatocellular carcinoma cell line (SK-Hep1)
Hippo signaling pathway is pivotally involved in human cancer. Among the Hippo components, YAP1 is highly active while function of MST1,2 and SAV1 was lost in liver cancer. Based on systematic analysis, we identified KLF5 as YAP1 binding partner in silico. To investigate KLF5 in liver cancer, we per...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-32597 | biostudies-arrayexpress
TranscriptomicsGene expression profile of TARDBP in hepatocellular carcinoma cell line (SK-Hep1)
TARDBP is TARDBP (TDP-43) is a DNA/RNA binding protein and was mutated in human amyotrophic lateral sclerosis (ALS). However, its function in human cancer has not been fully identified, yet.Thus, We carried out microarray to investigate the down-stream target genes of TARDBP after silencing TARDBP i...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-37640 | biostudies-arrayexpress
UnknownAllosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML.
Not available
S-EPMC10694768 | biostudies-literature
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