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MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
MetabolomicsArtificial fermentation with trichome exudate improves microbial community composition and leaf quality in cigar tobacco
Diterpenoids and sucrose esters are synthesized in cigar tobacco leave (CTLs) trichomes and secreted onto leaf surface as trichome exudate (TE), contributing to sensory quality.To reveal the mechanism by which TE affects CTLs quality, this study employed the half-leaf method, utilizing tobacco extra...
2026-06-17 | MTBLS14776 | MetaboLights
MetabolomicsDistinguishing smoke exposure from emerging pathology: Temporal metabolomic profiling in a rat model of cigarette smoke-induced lung injury
We set up four groups of rat models treated with smoking method at different times to evaluate and understand the development process of COPD from the onset to the stable stage. The animal models were verified by pathological experiments, and the serum and urine of rats were analyzed by mass spectro...
2026-10-29 | MTBLS15773 | MetaboLights
MetabolomicsBiological Responses to Tobacco Smoke Exposure in III Children: Inflammatory Processes and the Oral Microbiome
Not available
ORGANISM(S): Homo sapiens 
ST001200 | MetabolomicsWorkbench
MetabolomicsExamining the effects of cigarette smoke on mouse lens through a multi OMIC approach
Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...
2024-03-24 | MTBLS207 | MetaboLights
TranscriptomicsEndothelial cells and exposure to enviromental tobacco
Endothelial cells from mice exposed to enviromental tobacco smoke for 1 or 6 weeks.
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2090 | biostudies-arrayexpress
MetabolomicsThe impact of tobacco smoke exposure and environmental exposures on the pulmonary microbiome of critically ill children
Not available
ORGANISM(S): Homo sapiens 
ST001262 | MetabolomicsWorkbench
MetabolomicsDistinguishing smoke exposure from emerging pathology: Temporal metabolomic profiling in a rat model of cigarette smoke-induced lung injury
We set up four groups of rat models treated with smoking method at different times to evaluate and understand the development process of COPD from the onset to the stable stage.
2026-10-29 | MTBLS15779 | MetaboLights
TranscriptomicsTranscription profiling of human A549 and Calu-6 lung cancer reveals tobacco smoke induces Polycomb-mediated repression of Dickkopf-1 in lung cancer cells
Polycomb-mediated repression of Dkk-1 activates Wnt signaling and enhances tumorigenic potential of lung cancer cells following tobacco smoke exposure Experiment Overall Design: microarray techniques were used to examine proliferation and gene expression in A549 and Calu-6 lung cancer cells cultured...
ORGANISM(S): Homo sapiens 
2009-04-19 | E-GEOD-13309 | biostudies-arrayexpress
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