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MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
ProteomicsProteome wide measurements of protein half-lives in Mycoplasma pneumoniae
We obtained proteome wide measurements of protein half-lives in M. pneumoniae by performing pulse-chase experiments following SILAC methods. We estimated degradation rates of individual proteins by measuring the increase in light protein compared to heavy protein labeling along the growth curve.
ORGANISM(S): Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
2020-11-24 | PXD016386 | Pride
Degradation rates Protein half-life Silac 
TranscriptomicsDistinct small RNA populations act antagonistically in formation of heterosis
This research reports the analysis of sRNAs in 14 and 7 inbred lines from a breeding population. We analyzed the contribution of sRNAs to the formation of heterosis via integrative association analysis with field data of 98 hybrids generated from the set of inbred lines. Our results indicate a contr...
ORGANISM(S): Zea mays 
2016-10-24 | E-GEOD-51662 | biostudies-arrayexpress
TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
TranscriptomicsscRNA sequencing of the interventricular septum of mouse heart at E11.5 in control- and mutant embryos carrying a conditional dominant negative retinoic acid receptor in the SHF population displaying a defect in interventricular septal morphogenesis
The mammalian heart is divided into four chambers by septa that arose during vertebrate evolution to isolate the systemic and pulmonary circulation. Septation defects are the most common cause of congenital heart defects, however, it is not fully understood how they are formed during cardiogenesis. ...
ORGANISM(S): Mus musculus 
2026-09-14 | E-MTAB-17365 | biostudies-arrayexpress
UnknownActivation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.
Not available
S-EPMC2516408 | biostudies-literature
GenomicsMyrtle rust genome assembly
Austropuccinia psidii (pandemic) haploid genome assembly using PacBio sequence reads
PRJEB34084 | ENA
ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-27 | MSV000084240 | MassIVE
OtherPseudomonas aeruginosa clinical isolates
35 P. aeruginosa clinical strains were cultivated under standard conditions, characterized in terms of virulence and biofilm phenotype, and their metabolomes were investigated by untargeted liquid chromatography-mass spectrometry.
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2022-07-12 | MSV000089869 | MassIVE
Genomicsena-DATASET-LUMC-SASC-04-12-2017-12:12:33:008-298 - samples
Patient information SSc patients were recruited at the Department of Rheumatology of the Leiden University Medical Center (Leiden, The Netherlands). All patients met the American Rheumatism Association classification criteria for SSc (Subcommittee for scleroderma criteria 1980), and were classified ...
EGAD00001003832 | EGA
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