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TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
TranscriptomicsType-I interferon response profiling
Peripheral blood mononuclear cells were treated with beta-interferon for 2, 6 and 18 hours, and interferon-responsive genes identified. This 'signature' was then analysed in newly diagnosed and long-standing type-1 diabetics, as well as pre-diabetic children and individuals with systemic lupus eryth...
ORGANISM(S): Homo sapiens 
2014-03-13 | E-MTAB-1724 | biostudies-arrayexpress
GenomicsGenome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [ChIP-Seq]
Analysis of CTCF binding in Wehi-231 with TFII-I knockdown compare to Wehi-231 wt. ChIP experiment of CTCF in Wehi-231-CT and Wehi-231-shTFII-I
ORGANISM(S): Mus musculus 
2014-08-29 | E-GEOD-60917 | biostudies-arrayexpress
GenomicsRNA sequencing of murine ESC-derived cardiac progenitor cells treated with screening hit compound Cucurbitacin I Hydrate
RNA sequencing of murine ESC-derived cardiac progenitor cells treated with screening hit compound Cucurbitacin I Hydrate
PRJNA528273 | ENA
GenomicsAxl inhibition on dendritic cells enhances STING anticancer therapy through type I interferon signaling
Axl inhibition on dendritic cells enhances STING anticancer therapy through type I interferon signaling
PRJNA1185788 | ENA
UnknownAssociation analyses of the vitamin D receptor gene in 1654 families with type I diabetes.
Not available
S-EPMC2805827 | biostudies-literature
ProteomicsVincristine resistance reshapes sphingolipid composition and promotes mitochondrial complex I deficiency in acute myelogenous leukemia
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actio...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025645 | JPOST Repository
TranscriptomicsEffects of resistance exercise on the transcriptome in MHC I and MHC IIa muscle fibers of young and old women
Global microarray (HG U133 Plus 2.0) was used for the first time to investigate the effects of resistance exercise on the transcriptome in slow-twitch myosin heavy chain (MHC) I and fast-twitch MHC IIa muscle fibers of young and old women. Vastus lateralis muscle biopsies were obtained pre and 4hrs...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-28392 | biostudies-arrayexpress
ProteomicsProbing the HIV-Host Interactome in Infected Cells
Although genetically compact, HIV-1 commandeers vast arrays of cellular machinery that sustain and protect it during cycles of viral outgrowth. Transposon-mediated saturation linker scanning mutagenesis was used to isolate fully replication-competent viruses harboring a potent foreign epitope tag. U...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD003762 | Pride
Protein interactions Ap-ms Env I-dirt Vif 
TranscriptomicsThe Candida albicans regulator ZCF21 controls the expression of cell wall components
We report that a transcriptional regulator that originated in the lineage that gave rise to multiple host-associated Candida species is a key component of the circuitry that governs the C. albicans cell surface composition. Specifically, we show that the transcription regulator ZCF21 controls the ex...
ORGANISM(S): Candida albicans 
2015-11-01 | E-GEOD-73373 | biostudies-arrayexpress
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