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TranscriptomicsExpression data from colonic biopsy samples of infliximab treated ulcerative colitis patients
A gene expression profiling sub-study was conducted in which colonic biopsy samples were collected for RNA extraction and hybridization to microarrays from 48 patients with UC who were participating in ACT 1, a placebo-controlled study of infliximab. Gene expression profiles from infliximab responde...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23597 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ulcerative colitis samples reveals a predictive response signature to infliximab treatment in ulcerative colitis
Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predi...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-12251 | biostudies-arrayexpress
TranscriptomicsMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Infliximab, an anti-TNF-alpha monoclonal antibody, is an effective treatment for ulcerative colitis (UC) with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-TNF-alpha is unknown. This study used colonic mucosal gene expression to pr...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-GEOD-14580 | biostudies-arrayexpress
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