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TranscriptomicsDiverse routes to oral cancer differing in genome instability and risk for cervical node metastasis
Clinically evident oral lesions, oral epithelial dysplasia, precede development of oral squamous cell carcinomas (SCC) and are considered to transform to cancer by acquisition of genetic or epigenetic alterations. Here, we show that, +3q24-qter, -8pter-p23.1, +8q12-q24.2 and +20 are early events id...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-28407 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human breast tumor samples
Application of array comparative genomic hybridization (CGH) to the analysis of breast tumors
ORGANISM(S): Homo sapiens 
2006-11-27 | E-TABM-170 | biostudies-arrayexpress
TranscriptomicsRedefining the role of eIF4E dose in development, cancer, and protein synthesis
eIF4E, the major cap-binding protein, has long been considered limiting for translating the mammalian genome. However, the requirement for eIF4E dose at an organismal level remains unexplored. By generating an Eif4e haploinsufficient mouse, we surprisingly found that 50% reduction in eIF4E, while co...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-68238 | biostudies-arrayexpress
TranscriptomicsGenome position and gene amplification - expressional profiling of methotrexate resistant colonies
We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific d...
ORGANISM(S): Homo sapiens 
2007-10-08 | E-GEOD-6361 | biostudies-arrayexpress
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