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TranscriptomicsDNA methylation profiling of ductal carcinoma in situ (DCIS)
Methylated genomic fragments from tumor DNA and matching normal control were enriched with the methylated-CpG island recovery assay (MIRA); amplified, labeled and hybridized on Agilent CpG island tiling oligo arrays. MIRA enriched samples from tumor were labeled with Cy5 while MIRA enriched DNA samp...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-14865 | biostudies-arrayexpress
TranscriptomicsInvestigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells
Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer. In this study, we have comprehensively investigated the modulation of DNA methylation consequent to chro...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21532 | biostudies-arrayexpress
TranscriptomicsWhole DNA methylome profiling in mice exposed to secondhand smoke
A large body of evidence has linked secondhand smoke (SHS) to lung cancer in nonsmokers. Yet, the underlying mechanisms of SHS carcinogenicity in nonsmokers' lung cancer remain elusive. Recently, we have demonstrated a genotoxic mode of action for SHS, based on the ability of this carcinogen to indu...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41421 | biostudies-arrayexpress
TranscriptomicsMammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Progression to malignancy requires cells to overcome senescence and switch to an immortal phenotype. Thus, exploring the genetic and epigenetic changes that occur during senescence/immortalization may help elucidate crucial events that lead to cell transformation. In the present study, we have globa...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-39034 | biostudies-arrayexpress
TranscriptomicsAlterations of DNA methylome during chemical carcinogenesis
Similar to other genotoxic polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (BaP) is known to produce stable DNA adducts and other DNA damage. BaP is a powerful carcinogen and can induce tumors in the accessory sex organs (including prostate) of rodents. In the present study, we have invest...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-41422 | biostudies-arrayexpress
UnknownEmploying a systematic approach to biobanking and analyzing clinical and genetic data for advancing COVID-19 research.
Not available
S-EPMC7811682 | biostudies-literature
UnknownDiagnosis and management of urinary tract infections in children aged 2 months to 3 years in the Italian emergency units: the ItaUTI study.
Not available
S-EPMC9192484 | biostudies-literature
UnknownProtective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women.
Not available
S-EPMC8073081 | biostudies-literature
UnknownRare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients.
Not available
S-EPMC8703210 | biostudies-literature
UnknownAn explainable model of host genetic interactions linked to COVID-19 severity.
Not available
S-EPMC9606365 | biostudies-literature
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