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ProteomicsRAD54L2 mediates a novel mechanism to counter TOP2-DNA adducts
The catalytic cycle of topoisomerase 2 (TOP2) enzymes proceeds via a transient DNA double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in which the TOP2 protein is covalently bound to DNA. Anti-cancer agents such as etoposide operate by stabilising TOP2ccs, ultimately g...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046611 | Pride
Cancer Top2-dna adducts Etoposide Rad54l2 
UnknownRAD54L2 counters TOP2-DNA adducts to promote genome stability.
Not available
S-EPMC10699776 | biostudies-literature
UnknownMRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.
Not available
S-EPMC4754713 | biostudies-literature
UnknownUBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks.
Not available
S-EPMC7155233 | biostudies-literature
UnknownPosition-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.
Not available
S-EPMC218786 | biostudies-literature
UnknownTDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.
Not available
S-EPMC7497232 | biostudies-literature
UnknownGCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.
Not available
S-EPMC7227305 | biostudies-literature
UnknownDiscovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.
Not available
S-EPMC4939481 | biostudies-literature
UnknownMDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner.
Not available
S-EPMC10806188 | biostudies-literature
UnknownNovel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.
Not available
S-EPMC5137425 | biostudies-literature
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