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ProteomicsProteolytic Cleavage Activates the Mitochondrial Isoform of TOP3A
The TOP3A gene encodes two isoforms, one targeted to the nucleus and one to mitochondria. Nuclear TOP3A functions as part of the BTRR complex to resolve double Holliday junctions during homologous recombination, while the mitochondrial isoform separates hemicatenated daughter mitochondrial DNA molec...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD064926 | Pride
Top3a Mitochondria Mitochondrial processing peptidase (mmp) Proteolytic cleavage product 
ProteomicsProteolytic processing promotes the decatenation activity of human mitochondrial TOP3A; BioID
The TOP3A gene encodes protein products that are targeted to both the nucleus and to mitochondria. The nuclear isoform of TOP3A is required for the resolution of double Holliday junctions during homologous recombination, while the mitochondrial isoform of TOP3A separates hemicatenated daughter mitoc...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD063285 | Pride
Top3a Label-free Bioid 
Genomics
TOP3A
PRJNA1420161 | ENA
UnknownProteolytic cleavage activates the mitochondrial isoform of TOP3A.
Not available
S-EPMC12585908 | biostudies-literature
UnknownMutations in TOP3A Cause a Bloom Syndrome-like Disorder.
Not available
S-EPMC6080766 | biostudies-literature
UnknownPathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.
Not available
S-EPMC10165364 | biostudies-literature
GenomicsGenome-wide Mapping of Topoisomerase Binding Sites Suggests Topoisomerase 3a (TOP3A) as a Reader of Transcription-Replication Conflicts (TRC)
Both transcription and replication can take place simultaneously on the same DNA template, potentially leading to transcription-replication conflicts (TRCs) and topological problems. Here we asked which topoisomerase(s) is/are the best candidate(s) for sensing TRC. Genome-wide topoisomerase binding ...
ORGANISM(S): Homo sapiens 
2024-07-31 | GSE269841 | GEO
GenomicsGenome-wide Mapping of Topoisomerase Binding Sites Suggests Topoisomerase 3a (TOP3A) as a Reader of Transcription-Replication Conflicts (TRC)
Genome-wide Mapping of Topoisomerase Binding Sites Suggests Topoisomerase 3a (TOP3A) as a Reader of Transcription-Replication Conflicts (TRC)
PRJNA1123844 | ENA
UnknownTOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.
Not available
S-EPMC9549729 | biostudies-literature
UnknownAssociation between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
Not available
S-EPMC2685436 | biostudies-literature
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