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GenomicsIdentification of topologically associated domains (TADs) in peripheral blood CD34+ cells
Identification of topologically associated domains (TADs) in peripheral blood CD34+ cells
PRJNA780868 | ENA
TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
OtherIdentification of topologically associated domains (TADs) in peripheral blood CD34+ cells
We performed a Hi-C experiment on CD34+ cells isolated from peripheral blood and identifed topologically associated domains (TADs).
ORGANISM(S): Homo sapiens 
2022-09-16 | GSE188940 | GEO
GenomicsTopologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
PRJNA587064 | ENA
TranscriptomicsSpatial organisation of the X inactivation center
We report the application of Chromosome Conformation Capture Carbon-copy (5C) to a 4.5 Mb stretch of the mouse X chromosome encompassing the X inactivation center locus. We uncover a series of discrete 200kb-1Mb topologically associating domains (TADs). These align with several domain-wide epigenomi...
ORGANISM(S): Mus musculus 
2012-04-11 | E-GEOD-35721 | biostudies-arrayexpress
ProteomicsModeling of DNA methylation in cis reveals principles of chromatin folding in vivo in the absence of crosslinking and ligation
Mammalian chromosomes are folded into intricate hierarchies of interaction domains, within which topologically associating domains (TADs) and CTCF-associated loops partition the physical interactions between regulatory sequences. Current understanding of chromosome folding largely relies on chromoso...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-03 | PXD013507 | Pride
Proteomic ruler Tads Chromosomal interactions Mouse embryonic stem cells Ctcf-associated loops Topologically associating domains Chromosome folding 
UnknownAccurate prediction of boundaries of high resolution topologically associated domains (TADs) in fruit flies using deep learning.
Not available
S-EPMC6648328 | biostudies-literature
UnknownTopologically Associated Domains Delineate Susceptibility to Somatic Hypermutation.
Not available
S-EPMC6980758 | biostudies-literature
GenomicsTopologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes of activated B cells to support the process of antibody affinity maturation but also causes "off-target" mutations in other parts of the genome. We have used sensitive lentiviral SHM reporter vectors and a mutation...
ORGANISM(S): Homo sapiens 
2019-12-04 | GSE139810 | GEO
GenomicsGlucocorticoid stimulation induces regionalized gene responses within topologically associating domains
Glucocorticoid stimulation induces regionalized gene responses within topologically associating domains
PRJNA940425 | ENA
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