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MetabolomicsMetabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control

Cells maintain metabolite homeostasis (metabolostasis) by buffering fluctuations in metabolite levels, yet the limits of this buffering and the mechanisms underlying metabolic toxicity remain poorly understood. To study this, we systematically overfed metabolites in Saccharomyces cerevisiae and q...

2026-09-29 | MTBLS12080 | MetaboLights
MetabolomicsHolistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging

A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histop...

2022-04-07 | MTBLS2671 | MetaboLights
ProteomicsMulti-dimensional native proteomics technology for protein complex identification and topology characterization (Mud-NatPIT)
Here, we demonstrate a pilot development of multi-dimensional native proteomics technology for protein complex identification and topology characterization (Mud-NatPIT) in complex biological samples via coupling native size exclusion chromatography (SEC), online native capillary electrophoresis-mass...
ORGANISM(S): Escherichia coli 
2026-08-04 | PXD069439 | Pride
Capillary electrophoresis-mass spectrometry Protein complex identification Native proteomics Topology characterization Surface-induced dissociation 
MetabolomicsCharacterization of the heat-stable proteome during seed germination in Arabidopsis with special focus on LEA proteins
During seed germination, desiccation tolerance is lost in the radicle with progressing radicle protrusion and seedling establishment. This process is accompanied by comprehensive changes of the metabolome and proteome. Germination of Arabidopsis seeds was investigated over 72 h with special focus on...
2021-07-29 | MTBLS2980 | MetaboLights
MetabolomicsMulti-omic Molecular Characterization and Diagnostic Biomarkers for Occult Hepatitis B Infection and HBsAg-Positive Hepatitis B Infection

BACKGROUND: The pathological and physiological characteristics between HBsAg-positive HBV infection and occult hepatitis B infection (OBI) are currently unclear. This study aimed to explore the immune microenvironment in the peripheral circulation of OBI patients through integration of proteomic ...

2024-11-05 | MTBLS11406 | MetaboLights
UnknownGoing beyond base-pairs: topology-based characterization of base-multiplets in RNA.
Not available
S-EPMC6467009 | biostudies-literature
UnknownEllipsometric Characterization of Network Topology Transition in Vitrimers.
Not available
S-EPMC12713773 | biostudies-literature
GenomicsAltered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
PRJNA420090 | ENA
TranscriptomicsH. salinarum TrmB dynamics
Previous work characterized TrmB as a global glucose responsive metabolic transcription factor in archaeal extremophiles. However, it remains unclear how TrmB dynamically regulates its ~100 metabolic enzyme-coding genes. Using a dynamic perturbation approach, we elucidate the topology of the metabol...
ORGANISM(S): Halobacterium sp. NRC-1 
2013-08-07 | E-GEOD-47201 | biostudies-arrayexpress
GenomicsCharacterization of IL-1α–responsive enhancers and of IL-1α -mediated changes in chromatin topology.
Characterization of IL-1α–responsive enhancers and of IL-1α -mediated changes in chromatin topology.
PRJNA555101 | ENA
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