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TranscriptomicsCo-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43526 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spontaneous and transplanted topotecan-resistant BRCA1;P53-deficient mouse mammary tumors
Gene expression profiles of "spontaneous" and transplanted topotecan-resistant BRCA1;P53-deficient mammary tumors and their matched untreated controls
ORGANISM(S): Mus musculus 
2010-01-05 | E-NCMF-28 | biostudies-arrayexpress
TranscriptomicsPreclinical analysis of acquired resistance after prolonged efficacious metronomic oral topotecan chemotherapy plus pazopanib therapy in advanced ovarian carcinoma
An alternative or follow-up adjunct to conventional maximum tolerated dose (MTD) chemotherapy now in advanced phase III clinical trial assessment is metronomic chemotherapy?the close regular administration of low doses of drug with no prolonged breaks. A number of preclinical studies have shown metr...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-54621 | biostudies-arrayexpress
TranscriptomicsToxicogenomics profiling of bone marrow from rats treated with topotecan in combination with oxaliplatin: a mechanistic strategy to inform combination toxicity.
Combinations of anticancer agents may have synergistic anti-tumor effects, but enhanced hematological toxicity often limit their clinical use. We examined whether M-bM-^@M-^\microarray profilesM-bM-^@M-^] could be used to compare early molecular responses following a single dose of agents administer...
ORGANISM(S): Rattus norvegicus 
2015-01-21 | E-GEOD-63902 | biostudies-arrayexpress
ModelsEvans2004 - Cell based mathematical model of topotecan
A two compartment mathematical model of the antineoplastic compound topotecan
2024-09-02 | BIOMD0000000945 | BioModels
ModelsEvans2005 - Compartmental model for antineoplastic drug topotecan in breast cancer cells
Compartment model for the antineoplastic drug topotecan. Modelling drug in its active lactone and inactive hydroxy acid forms in the medium, extracellular, cytoplasm and nucleus.
2024-09-02 | BIOMD0000000946 | BioModels
TranscriptomicsCo-ordinate inhibiton of autism candidate genes by topoisomerase inhibitors [array]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43899 | biostudies-arrayexpress
GenomicsEffects of ascorbic acid on topotecan-induced DNA damage in human tumor cells
Effects of ascorbic acid on topotecan-induced DNA damage in human tumor cells
PRJNA575871 | ENA
ClinicalWeekly Topotecan in Patients Treated for Metastatic Colorectal Cancer
This non-randomized phase II study is designed to assess the response rate and toxicity of weekly topotecan as second-line treatment in patients with relapsed or refractory metastatic colorectal cancer.
2018987 | ecrin-mdr-crc
ProteomicsMulti-Omics Analysis Revealed Significant Metabolic Changes in Brain Cancer Cells Treated with Paclitaxel and/or Topotecan
Glioblastoma (GB) is the most common primary malignant brain tumor, representing approximately 57% of all gliomas and 48% of all primary malignant central nervous system (CNS) tumors. Despite the best standard therapies, glioblastoma survivors have a brief survival time, about 24 months on average. ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052027 | Pride
Metabolomics Glioblastoma Proteomics 
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