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TranscriptomicsIdentification of glucose-TOR signaling early target genes in Arabidopsis seedling autotrophic transition stage
The goal of this experiment was to explore the molecular network of glucose-TOR signaling in Arabidopsis seedling autotrophic transition stage. We used the whole-genome microarrays to detail the global program of gene expression mediated by glucose and TOR. Arabidopsis WT and estradiol inducible RNA...
ORGANISM(S): Arabidopsis thaliana 
2013-04-05 | E-GEOD-40245 | biostudies-arrayexpress
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
TranscriptomicsIdentification of new target genes of TOR during growth in MDN
To identify novel targets of TOR when prototrophic strain S288c is grown in MDN media. Arrays compare growth in MDN with and without addition of rapamycin. For comparison, growth in YPD versus MDN as well as SCD versus MDN were examined as well.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-30 | E-GEOD-3157 | biostudies-arrayexpress
ProteomicsPost-translational regulation of photosynthetic activity via the TOR kinase in plants.
Chloroplasts are the powerhouse of the plant cell, and their activity must be matched to plant growth to avoid photo-oxidative damage. We have identified a post-translational mechanism linking the conserved Target of Rapamycin (TOR) kinase that promotes growth and the guanosine tetraphosphate (ppGpp...
ORGANISM(S): Nicotiana benthamiana 
2024-05-03 | PXD047124 | Pride
Photosynthesis Phosphorylation Tor kinase Guanosine tetraphosphate signaling Ppgpp 
TranscriptomicsExploring the scope of TOR/PKA co-regulation in MDN
To identify genes co-regulated by TOR and PKA during growth in MDN BCY1, bcy1 deletion, TPK, and tpk1-3 deletion strains were grown in MDN with and without rapamycin treatment. Different combinations of these samples were examined.
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-3160 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast to investigate the role of the TORC2 complex in gene expression, DNA metabolism and damage response
Investigating the role of TORC2 complex in gene expression, DNA meatbolism and DNA damage response
ORGANISM(S): Schizosaccharomyces pombe 
2009-07-01 | E-MTAB-39 | biostudies-arrayexpress
TranscriptomicsSynergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth
The experiments were designed to interrogate the genetic interaction relationship between the TOR signalling pathway and the UPS-proteasome pathway in gene expression and cell growth. Yeast cells (BY4742pdr5delta) were treated with the drug vehicle, MG132 (50uM), rapamycin (200ng/ml) or both drugs. ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-24 | E-MTAB-1550 | biostudies-arrayexpress
ProteomicsFunctional Characterization of Target of Rapamycin (TOR) Signalling in Physcomitrella
Target of rapamycin (TOR) is a structurally and functionally conserved protein kinase and an important signalling hub in eukaryotes. The moss Physcomitrella (Physcomitrium patens) is a model organism for plant physiology, development, and evolution. However, little is known about TOR signalling in n...
ORGANISM(S): Physcomitrella Physcomitrella patens subsp. patens (Moss) 
2026-02-09 | PXD069889 | Pride
Physcomitrella Tor signalling 
TranscriptomicsVibrio cholerae: Wild type El Tor biotype versus crp mutant
Transcriptional profiling of an El Tor biotype crp mutant The virulent V. cholerae El Tor Ogawa strain C7258 (Peru isolate 1991) and an isogenic deletion mutant (WL7258) lacking DNA sequences encoding the cAMP receptor protein were grown in LB medium to optical density at 600 nm of 1.5. The cultures...
ORGANISM(S): Vibrio cholerae 
2010-05-27 | E-GEOD-7519 | biostudies-arrayexpress
ProteomicsNitrogen starvation leads to TOR kinase-mediated downregulation of fatty acid synthesis in the algae Chlorella sorokiniana and Chlamydomonas reinhardtii
The accumulation of triacylglycerol (TAG) as a storage compound in eukaryotic algae has been the subject of extensive studies over the last 25 years. The model industrial alga Chlorella sorokiniana accumulates TAG and other storage compounds under nitrogen (N)-limited growth. Previously we used tran...
ORGANISM(S): Chlorella sorokiniana 
2024-10-17 | PXD041691 | Pride
Phosphoproteomics Fatty acids Chlorella Tor Label-free Lc-ms/ms 
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