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ProteomicsDepletion Assisted Hemin Affinity (DAsHA) Proteomics Reveals an Expanded Landscape of Heme Binding Proteins in the Human Proteome
Heme b (iron protoporphyrin IX) plays important roles in biology as a metallocofactor and signaling molecule. However, the targets of heme signaling and the network of proteins that mediate the exchange of heme from sites of synthesis or uptake to heme dependent or regulated proteins are poorly unde...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037165 | Pride
Heme Heme trafficking Proteomics Heme binding protein Cell stress Heme affinity Hemin agarose Labile heme pool 
ProteomicsSod1 Integrates Oxygen Availability to Redox Regulate NADPH Production and the Thiol Redoxome
Redox proteomics identifies additional putative targets of Sod1 redox regulation. The high abundance and broad cellular distribution of Sod1 suggests that it may function as a redox regulator of a broad variety of substrates in addition to GAPDH. To test this, we conducted a high-powered quantitativ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-01-04 | PXD030372 | Pride
Pentose phosphate pathway Superoxide dismutase Oxygen sensing Redox signailng Glycolysis 
ProteomicsIdentification of glutathionylated cysteine in decellularized extracellular matrix
Strain-dependent glutathionylation of fibronectin fibers impacts mechano-chemical behavior and primes an integrin switch
ORGANISM(S): Homo sapiens (Human) 
2024-09-28 | PXD053496 | Pride
Glutathionylation Lc-ms Fibronectin Human 
MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
ProteomicsSaanich inlet water column metaproteomes
Metaproteomics and metagenomics of bacterial species in the seasonally anoxic fjord Saanich Inlet
ORGANISM(S): environmental samples 
2017-10-31 | PXD004433 | Pride
Metaproteomics Microbial Marine 
TranscriptomicsFNR- vs WT in anoxic conditions
Salmonella enterica var. Typhimurium (S. Typhimurium) is a Gram-negative, facultative intracellular pathogen that infects the intestinal tracts of humans and animals. In the host, S. Typhimurium encounters a wide range of oxygen concentrations going from oxic conditions in the stomach to near anoxic...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2010-07-01 | E-GEOD-3657 | biostudies-arrayexpress
ProteomicsMolecular determinants of tumor response to hyperthermia
Proteomic data from ovarian cancer cells (A2780 and SKOV3); treated cells with or without hyperthermia (46 deg C for 1 hr); 2 biological replicates for each cell line/condition
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD005055 | Pride
Hyperthermia Proteomics Tmt 
Genomicsena-DATASET-UNIBE-07-04-2016-07:41:15:505-596 - samples
Mapped data (bam files) for high-throughput whole genome sequence data for 83 modern Aboriginal Australians
EGAD00001002001 | EGA
Genomics37a30206-29b3-47a0-90c4-eee326fe5b8b - samples
Genotype calls for 83 Aboriginal Australian genomes split by chromosomes. In short, genotypes were called individually with samtools. They were subsequently filtered with thresholds related to sequencing depth, location of variants, sequencing error, and strand bias. Once combined, the genotypes wer...
EGAD00001004155 | EGA
GenomicsRFMix
This dataset contains the per-chromosome RFMix input and output files for the local ancestry inference of 59 Aboriginal Australian genomes as reported in Malaspinas et al., 2016. Local ancestry was inferred assuming four mixing ancestral populations represented by: Europeans (27 individuals), Asians...
EGAD00010001575 | EGA
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