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TranscriptomicsCCAAT/enhancer-binding protein alpha target genes in myeloid progenitor cells uncovered by chromatin IP
CCAAT/enhancer-binding protein alpha (C/EBPM-NM-1) is a lineage-specific transcription factor that directs development of granulocytes. To obtain insights into the genome-wide transcriptome of wild type C/EBPM-NM-1, we have performed chromatin immunoprecipitation on DNA promoter microarrays (ChIP-ch...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-19321 | biostudies-arrayexpress
TranscriptomicsMutant-CCAAT/enhancer-binding protein alpha target genes in myeloid progenitor cells by chromatin IP
CCAAT/enhancer-binding protein alpha (C/EBPM-NM-1) is a lineage-specific transcription factor that directs development of granulocytes. To obtain insights into the genome-wide transcriptome of mutant C/EBPM-NM-1, we have performed chromatin immunoprecipitation on DNA promoter microarrays (ChIP-chip)...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-36268 | biostudies-arrayexpress
TranscriptomicsRetroviral Integration Mutagenesis in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression as a Prognostic Indicator
Acute myeloid leukemia (AML) results from multiple genetic and epigenetic aberrations, many of which remain unidentified. Frequent loss of large chromosomal regions marks haplo-insufficiency as one of the major mechanisms contributing to leukemogenesis. However, which haplo-insufficient genes (HIGs)...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-19706 | biostudies-arrayexpress
TranscriptomicsDicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice
MiRNAs have the potential to regulate cellular differentiation programs. However, miRNA-deficiency in primary hematopoietic stem cells (HSCs) results in HSC depletion in mice, leaving the question of whether miRNAs play a role in early-lineage decisions unanswered. To address this issue, we deleted ...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-35844 | biostudies-arrayexpress
TranscriptomicsRibosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Diamond Blackfan Anemia (DBA) is associated with developmental defects and profound anemia. Mutations in genes encoding a ribosomal protein of the small (e.g. Rps19) or large (e.g. Rpl11) ribosomal subunit are found in over half of these patients. The mutations cause ribosomal haploinsufficiency, ...
ORGANISM(S): Mus musculus 
2011-11-14 | E-GEOD-22903 | biostudies-arrayexpress
TranscriptomicsAnalysis of differential gene expression in Cebpa-positive and Cebpa-negative hematopoietic stem cells using a Cebpa-Cre EYFP reporter mouse model
C/EBPalpha is a transcription factor critically involved in myeloid development and indispensable for formation of granulocytes. To track the cellular fate of stem and progenitor (LSK) cells, which express C/EBPalpha, we developed a mouse model expressing Cre recombinase from the Cebpa promoter and ...
ORGANISM(S): Mus musculus 
2010-08-26 | E-GEOD-23800 | biostudies-arrayexpress
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