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TranscriptomicsTranscription profiling of human Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis patients blister cells from skin lesions reveals these consist of cytotoxic T cells annd NK cells
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis; (TEN) are life-threatening adverse drug reactions characterized; by massive epidermal necrosis, in which the specific danger; signals involved remain unclear. Here we show that blister; cells from skin lesions of SJS-TEN primarily consis...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13727 | biostudies-arrayexpress
UnknownScoring Assessments in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Not available
S-EPMC9245022 | biostudies-literature
GenomicsTargeting JAK1/3-STAT1 signaling attenuates cytotoxic T lymphocytes activation for the treatment in Stevens-Johnson syndrome and toxic epidermal necrolysis
Targeting JAK1/3-STAT1 signaling attenuates cytotoxic T lymphocytes activation for the treatment in Stevens-Johnson syndrome and toxic epidermal necrolysis
PRJNA1471675 | ENA
UnknownResearch Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Not available
S-EPMC5805563 | biostudies-literature
TranscriptomicsTargeting JAK1/3-STAT1 signaling attenuates cytotoxic T lymphocytes activation for the treatment in Stevens-Johnson syndrome and toxic epidermal necrolysis
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse reactions (SCARs). We integrate single-cell and spatial transcriptomic analyses on blood, blisters, and lesional skin from SJS/TEN patients, revealing IFN-γ and JAK/STAT signaling as the...
ORGANISM(S): Homo sapiens 
2026-06-25 | GSE333617 | GEO
UnknownStevens-Johnson syndrome and toxic epidermal necrolysis in pregnant patients: A systematic review.
Not available
S-EPMC7522894 | biostudies-literature
UnknownStevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology-Thirty Years of Progress but Still Much to Be Done.
Not available
S-EPMC5567821 | biostudies-literature
UnknownNeutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis.
Not available
S-EPMC9392155 | biostudies-literature
UnknownTNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis.
Not available
S-EPMC7243041 | biostudies-literature
UnknownPruritus as an early sign of abnormal scarring in the re-epithelialising phase of Toxic Epidermal Necrolysis.
Not available
S-EPMC10395619 | biostudies-literature
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