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TranscriptomicsTranscription profiling of human cells treated with Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers
We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours Experiment Overall Design: Three experimental conditions with two biological replicates for the control condition corresponding to untreated HUVEC monolayer. RNA were extr...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-GEOD-12131 | biostudies-arrayexpress
TranscriptomicsRNA-seq for identifying toxin MazF and MqsR cleavage sites in toxin expression and subsequent recovery cultures of Escherichia coli (mRNA and ncRNA excluding rRNA)
Bacterial toxin-antitoxin systems are thought to help bacteria to reduce their metabolism in various stressful conditions. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been mostly viewed as degraders of mRNA, however recently it was demonstrated that they ...
ORGANISM(S): Escherichia coli K-12 
2018-10-11 | E-MTAB-6993 | biostudies-arrayexpress
TranscriptomicsInducible expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA
In this study RNA-seq analysis of M. tuberculosis H37Rv overexpressing HigB compared to the empty vector control strain has been performed in order to investigate the role of the HigB toxin
ORGANISM(S): Mycobacterium tuberculosis 
2013-09-16 | E-MTAB-1667 | biostudies-arrayexpress
ProteomicsMajor determinants of airway epithelial cell sensitivity to S. aureus alpha-toxin: Disposition of toxin heptamers by extracellular vesicle formation and lysosomal degradation
Alpha-toxin is a major virulence factor of Staphylococcus aureus and plays an important role in S. aureus-induced pneumonia. Different sensitivities toward the toxin of various host cell types have been observed. In this study we investigated internalization of pore-containing areas of the plasma me...
ORGANISM(S): Homo sapiens (Human) 
2021-04-20 | PXD023678 | Pride
Cellular sensitivity Alpha-toxin Airway epithelial cells Virulence factors Staphylococcus aureus Transmembrane pores 
TranscriptomicsToxin-antitoxin of Rickettsia determines fatal addiction of the host cells
Rickettsia spp. can cause mild to severe human disease. These intracellular bacteria are associated with arthropods, nematodes and trematodes, and usually, are efficiently transmitted transovarially to the progeny of the invertebrate host. We recently demonstrated foreign gene acquisition by lateral...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-22072 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HMVEC cells treated with vascular endothelial growth factor, anthrax edema toxin, and an Epac activator
Human microvascular endothelial cells (HMVEC) treated with vascular endothelial growth factor (VEGF), Antrhax Edema Toxin (ET), or the Epac activator, 8-pCPT-2'-O-Me-cAMP (8CPT); Human microvascular endothelial cells (HMVEC) were treated with VEGF alone or VEGF in combination with either the the Epa...
ORGANISM(S): Homo sapiens 
2009-09-13 | E-GEOD-17777 | biostudies-arrayexpress
TranscriptomicsE. coli BW25113 K-12 hfq vs. wild-type persister
Persisters are cells which evade stresses like antibiotics and which are characterized by reduced metabolism and a lack of genetic alterations required to achieve this state. We showed previously that MqsR and MqsA of Escherichia coli are a toxin-antitoxin pair that influence cell physiology (e.g.,...
ORGANISM(S): Escherichia coli 
2009-11-07 | E-GEOD-18852 | biostudies-arrayexpress
ProteomicsThe novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur
Type II Toxin-antitoxin (TA) systems are widely distributed in bacterial and archaeal genomes with diverse critical cellular functions such as defense against phages, biofilm formation, persistence and virulence. GCN5-related N -acetyltransferase (GNAT) toxin, with an acetyltransferase activity-dep...
ORGANISM(S): Pseudomonas Aeruginosa Pa14 
2022-05-05 | PXD033699 |
UnknownPotential Prepore Trimer Formation by the Bacillus thuringiensis Mosquito-specific Toxin: MOLECULAR INSIGHTS INTO A CRITICAL PREREQUISITE OF MEMBRANE-BOUND MONOMERS.
Not available
S-EPMC4543642 | biostudies-literature
TranscriptomicsEffects of E. coli Shiga toxin on the gene expression profile of human microvascular endothelial cells
Changes in endothelial phenotype induced by E. coli-derived Shiga toxins (Stx) are believed to play a critical role in the pathogenesis of hemolytic uremic syndrome. Stx inactivate host ribosomes, but also alter gene expression at concentrations that minimally affect global protein synthesis. The ef...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-32710 | biostudies-arrayexpress
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