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UnknownCarbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia.
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S-EPMC6831888 | biostudies-literature
TranscriptomicsGenomic profiles of oxidative stress-induced rat renal cell carcinomas
Intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA) initiates Fenton reaction in the renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatment. We performed high-resolution microarray comparative genomic hybridi...
ORGANISM(S): Rattus norvegicus 
2012-08-30 | E-GEOD-36101 | biostudies-arrayexpress
TranscriptomicsChromosomal aberration of asbestos-induced malignant mesothelioma in rats
Exposure to asbestos is a risk for malignant mesothelioma in humans. We carried out array comparative genomic hybridization (CGH) analysis in a rat model by repeated intraperitoneal injections of three types of asbestos including chrysotile, crocidolite and amosite. We found a common chromosomal del...
ORGANISM(S): Rattus norvegicus 
2012-08-13 | E-GEOD-36577 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of cultured adipocytes treated with different types of asbestos fibers
We hypothesized that adipocytes can be triggered by asbestos fibers to produce an inflammatory response. Microarray-based gene expression analysis was thus carried out to identify potential inflammation-related candidates with altered expression in adipocytes following asbestos exposure. We found ch...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-42330 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of mesothelioma induced by intraperitoneal injections of asbestos in rats
Human malignant mesothelioma (MM) is an aggressive tumor strongly associated with asbestos exposure. SM patients generally have poorer prognosis compared to EM patients. To identify potential genes accounting for the differential prognosis between these two subtypes, we compared the microarray gene ...
ORGANISM(S): Rattus norvegicus 
2014-06-04 | E-GEOD-48298 | biostudies-arrayexpress
MetabolomicsFatal COVID-19 pulmonary disease involves ferroptosis.

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic an...

2024-07-11 | MTBLS3107 | MetaboLights
TranscriptomicsPre-miR-375_A549 vs. Pre-miR-NC#2 (Ambion) _A549
We investigated the functional significance of ASH1-inducible miR-375 in terms of biologic phenotypes of ASH1-positive lung cancer cells. To this end, we conducted genome-wide expression profiling analysis of miR-375-transfected A549 cells. Microarray analysis using a Whole Human Genome 4 x 44K Micr...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-31566 | biostudies-arrayexpress
TranscriptomicsASH1_A549 vs. vector control_A549
We performed genome-wide expression profiling of miRNAs in order to search for those significantly affected by ASH1 transduction in a lung cancer cell line. Microarray analysis was?conducted to examine miRNA expression profiles using a Human miRNA Microarray, pre-commercial version 6.0 (Agilent) wit...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-31565 | biostudies-arrayexpress
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