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ProteomicsCryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.
The haematopoietic cytokine thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for maintenance of the haematopoetic stem cell compartment. Tpo is a heavily glycosylated, hepatocyte-derived cytokine which functions by binding to its receptor (TpoR) on ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD046926 | Pride
Glycosylation Tpor Cryo-em 
GenomicsTPOR complex structure-driven analogs of TPO
Structure of the TPOR complex guides design of analogs that bias hematopoiesis
PRJEB61988 | ENA
TranscriptomicsPathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression
Transient abnormal myelopoiesis (TAM) is a human myeloid leukemia that occurs in newborns with Trisomy 21, who acquire mutations in the transcription factor GATA1. TAM originates in the fetal liver but spontaneously regresses as hemopoiesis transitions from fetal liver to postnatal bone marrow, unle...
ORGANISM(S): Homo sapiens 
2025-07-31 | GSE298857 | GEO
GenomicsPathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression
Pathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression
PRJNA1271516 | ENA
GenomicsPathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression [CUT&Tag]
Transient abnormal myelopoiesis (TAM) is a human myeloid leukemia that occurs in newborns with Trisomy 21, who acquire mutations in the transcription factor GATA1. TAM originates in the fetal liver but spontaneously regresses as hemopoiesis transitions from fetal liver to postnatal bone marrow, unle...
ORGANISM(S): Homo sapiens 
2025-08-20 | GSE298910 | GEO
GenomicsPathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression [CUT&Tag]
Pathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression [CUT&Tag]
PRJNA1271778 | ENA
ProteomicsOncogenic CALR Mutant C-terminus Mediates Dual Binding to the Thrombopoietin Receptor Triggering Complex Dimerization and Activation
Calreticulin (CALR) is a master lectin chaperone that guides the proper folding of integral membrane proteins in the endoplasmic reticulum. In healthy cells, CALR transiently and non-specifically interacts with thousands of immature N-glycosylated proteins through its N-terminal glycan-binding domai...
ORGANISM(S): Homo sapiens (Human) 
2023-04-11 | PXD034131 | Pride
Hdx-ms 
UnknownAutophagosome-lysosome mediated secretion of the thrombopoietin receptor is modulated by distinct driver mutations of myeloproliferative neoplasm.
Not available
S-EPMC12380609 | biostudies-literature
TranscriptomicsExpanding Hematopoietic Stem Cell pool through Fine tuning of Tpo receptor with diabodies.
Class I cytokine receptors such as Thrombopoietin receptor (MPL) are dimers, but it is unclear whether remodeling receptor dimer topology is a viable strategy to "tune" signaling output. We utilized diabodies (DA) as surrogate ligands in a prototypical dimeric receptor-ligand system, the cytokine Th...
ORGANISM(S): Homo sapiens 
2021-02-01 | GSE115235 | GEO
UnknownOncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation.
Not available
S-EPMC10076285 | biostudies-literature
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