TRAIL is a TNF family ligand that trimerizes upon engaging TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NFκB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts as a do...
ORGANISM(S): Homo sapiens (Human)
