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GenomicsInduction of trained immunity by influenza vaccine: impact on COVID-19
Cross-protective effects of certain vaccines against heterologous infections have been reported, and long-term boosting of innate immunity (also termed trained immunity) has been proposed as the underlying mechanism. Several epidemiological studies suggested cross-protection between influenza vaccin...
EGAS00001005446 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsHydroxychloroquine inhibits trained immunity
Hydroxychloroquine inhibits trained immunity
PRJNA670179 | ENA
TranscriptomicsRNA-seq analysis of LPS-trained bone marrow derived macrophages (BMDMs) reveals altered glutamine and glycolysis metabolic pathways
The aim of this study is to evaluate data by comparing transcriptome profile (RNA-seq) of BMDMs trained with low-dose LPS and untrained BMDMs. Trained immunity enables innate immune cells to acquire memory-like responses, offering a promising strategy to enhance antitumor immunity. However, the meta...
ORGANISM(S): Mus musculus 
2026-06-24 | E-MTAB-16184 | biostudies-arrayexpress
GenomicsA single cell view on host immune transcriptional response to in vivo BCG-induced trained immunity
Bacillus Calmette-Guerin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results in a more effective response of innate immune cells upon stimulation with heterologous stimuli. Here we investigated the heterogeneity of TI induction by single-cell RNA-seq ...
EGAS00001006990 | EGA
GenomicsBLUEPRINT DNase accessibility of Epigenetic programming during monocyte to macrophage differentiation and trained innate immunity
Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. Transcriptomes and epigenomes in four...
EGAS00001000954 | EGA
GenomicsBLUEPRINT RNA-seq of Epigenetic programming during monocyte to macrophage differentiation and trained innate immunity
Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. Transcriptomes and epigenomes in four...
EGAS00001000953 | EGA
GenomicsEpigenetic programming during monocyte to macrophage differentiation and trained innate immunity
Monocyte differentiation into macrophages represents one of the cornerstone processes in innate host defense. In addition, immunological imprinting of either tolerance or trained immunity after an initial infection determines the functional fate of innate immune cells and the susceptibility of the h...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-58310 | biostudies-arrayexpress
GenomicsTrained immunity suppression determines kidney allograft survival
Trained immunity suppression determines kidney allograft survival
PRJNA1180533 | ENA
GenomicsTrained Immunity Causes Myeloid Cell Hypercoagulability
Trained Immunity Causes Myeloid Cell Hypercoagulability
PRJNA1140546 | ENA
GenomicsBLUEPRINT ChIP-seq of Epigenetic programming during monocyte to macrophage differentiation and trained innate immunity
Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. Transcriptomes and epigenomes in four...
EGAS00001000951 | EGA
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