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TranscriptomicsTranscription profiling by array of human prostate from patients with a previous diagnosis of Prostatic Intraepithelial Neoplasia and following consumption of high glucosinolate broccoli or peas to investigate interactions with the GSTM1 genotype
Twenty-two male volunteers aged 30-70 years with a previous diagnosis of Prostatic Intraepithelial Neoplasia (PIN) were recruited by a consultant urologist at Norfolk and Norwich University Hospital NHS Trust. Ethical approval for the trial was obtained from the Norfolk Research Ethics Committee (re...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-MEXP-1243 | biostudies-arrayexpress
TranscriptomicsInvestigating NAFLD from RNA-seq data (human cell line Huh7) for samples under three treatments: low fat low sugar, low fat high sugar and high fat high sugar. Wild type samples are compared against DGAT2 knocked out.
Non-alcoholic fatty liver disease (NAFLD) is a major public health burden and it covers a spectrum of diseases. NAFLD starts with the accumulation of lipid droplets (LDs) within hepatocytes (steatosis). Part of the challenge of studying the mechanistic processes involved in LD accumulation and their...
ORGANISM(S): Homo sapiens 
2020-08-21 | E-MTAB-7884 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon Caco-2 cells treated with hydroxytyrosol (HTy) and hydroxytyrosyl ethyl ether (HTy-Et)
The anticarcinogenic activity of hydroxytyrosyl ethyl ether (HTy-Et) compared to its precursor hydroxytyrosol (HTy) has been studied in human Caco-2 colon adenocarcinoma cells. Changes in global gene expression in Caco-2 cells exposed to HTy and HTy-Et for 24 h were evaluated using Affymetrix array....
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-38833 | biostudies-arrayexpress
MetabolomicsThe Effect of Dietary BIoactives on Gut Microbiome DivErsity (DIME) - A pilot study (Untargeted metabolomics)

The gut microbiome refers to the complex community of microorganisms (bacteria, fungi, archaea and viruses) present within our gut. The composition and complexity of gut microbiota communities are crucial for maintaining human health. Humans depend on the gut microbiota to undertake essential met...

2025-10-10 | MTBLS8100 | MetaboLights
MetabolomicsThe Effect of Dietary Bioactives on Gut Microbiome DivErsity (DIME) - A pilot study (Targeted metabolomics)

The gut microbiome refers to the complex community of microorganisms (bacteria, fungi, archaea and viruses) present within our gut. The composition and complexity of gut microbiota communities are crucial for maintaining human health. Humans depend on the gut microbiota to undertake essential met...

2025-10-10 | MTBLS7290 | MetaboLights
TranscriptomicsTranscriptional differences between the peripheral and the transcription zone of the prostate
The occurrence of cancer is not equally distributed across the three zones of the prostate gland; the peripheral (PZ), central and transition zones (TZ). The majority (~70%) of diagnosed prostate cancer (PCa) is found in the PZ compared to the TZ. In this study we comprehensively measure whole geno...
ORGANISM(S): Homo sapiens 
2017-07-04 | E-MTAB-5021 | biostudies-arrayexpress
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