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GenomicsWGS of a serie of Arabidopsis thaliana tetrad's products to study the role of RECQ4A, RECQ4B, FIGL1 and FANCM genes in the rate, nature and distribution of meiotic recombination products (CO and NCO)
In this study, two accessions of Arabidopsis thaliana (Columbia and Landsberg erecta) were crossed and tetrads were obtained using thanks to the the quartet mutation, which keeps the 4 haploid pollen grains from a single meiosis attached together. By fertilising a plant (of ecotype Columbia) with a ...
ORGANISM(S): Arabidopsis thaliana 
2024-12-02 | E-MTAB-14435 | biostudies-arrayexpress
UnknownPhase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors.
Not available
S-EPMC5978471 | biostudies-literature
UnknownGenome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Not available
S-EPMC6366343 | biostudies-literature
ProteomicsKinome profiling of venetoclax-resistant wild type and NRAS-G12C MOLM-14 cells
Despite efficacy of FLT3 and BCL2 inhibition in acute myeloid leukemia (AML), relapse limits survival. Mutation status and AML monocytic differentiation are implicated in resistance. On-treatment tumor evolution may select for genetically distinct clones or shifts in differentiation not resolvable ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD068585 | Pride
Venetoclax Gilteritinib Kinase Inhibitor Bead Aml 
TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
TranscriptomicsSilver Nanowire Exposure Results in Internalization and Toxicity to Daphnia magna
Nanowires (NWs), high-aspect-ratio nanomaterials, are increasingly used in technological materials and consumer products and may have toxicological characteristics distinct from nanoparticles. We carried out a comprehensive evaluation of the physicochemical stability of four silver nanowires (AgNWs)...
ORGANISM(S): Daphnia magna 
2013-12-31 | E-GEOD-47064 | biostudies-arrayexpress
TranscriptomicsEffects of vitamin A on ventricular myocardium gene expression [left ventricle]
LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age and gender matched wildtype mice on a vitamin A sufficient diet RNA was isolated from the left ventricle of the heart and one array was run for each sample.
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-74904 | biostudies-arrayexpress
TranscriptomicsEffects of vitamin A on Ventricular myocardium gene expression [right ventricle]
LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age-matched wild type mice on a vitamin A sufficient diet RNA was isolated from right ventricle of the heart and one array was run for each sample.
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-74905 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of in vitro matured bovine oocytes cultivated with or without cumulus cells.
Cumulus cells, surrounding the oocyte, play a key role in the acquisition of oocyte competence to be fertilized and to sustain early embryo development. Cumulus cells contribute to oocyte development by metabolizing energy substrates such as glutathione that may protect the oocyte from oxidative str...
ORGANISM(S): Bos taurus 
2011-08-16 | E-GEOD-31361 | biostudies-arrayexpress
TranscriptomicsRNA-seq of gonadal adipose tissue from male and female Trim28-WT and Trim28 adipose specific KO mice
Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in embryonic development. We set out to determine if adipose specific deletion of Trim28 led to changes in adipose ti...
ORGANISM(S): Mus musculus 
2020-11-25 | E-MTAB-9809 | biostudies-arrayexpress
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