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MetabolomicsLysine acetyltransferase Rv0998 coordinates transcriptional and metabolic adaptation of Mycobacterium tuberculosis to acidic pH

Mycobacterium tuberculosis (Mtb) survives host defences by adapting to host conditions, including acid stress, during infection. A critical survival strategy involves pH homeostasis, mediated by complex signalling systems that regulate metabolic reprogramming and stress responses. While ...

2026-09-03 | MTBLS15171 | MetaboLights
ProteomicsSts2, a transcriptional activator effector of Ustilago maydis, regulates hyperplasia in maize during pathogen-induced tumor formation
Ustilago maydis causes common smut in maize, which is characterized by tumor formation in aerial parts of maize. Tumor comes from the de novo cell division of highly developed bundle sheath and subsequent cell enlargement. However, its mechanism is still unknown. Here, we characterize the U. maydis ...
ORGANISM(S): Zea mays (Maize) 
2023-10-12 | PXD040350 | Pride
Ustilago maydis Bundle sheath Transcriptional activator Hyperplasia tumor Leaf developmental regulator 
GenomicNAB2-STAT6 Gene Fusions in Solitary Fibrous Tumor by Integrative Sequencing

Transcriptome sequencing of solitary fibrous tumors / hemangiopericytomas from a variety of anatomic sites revealed recurrent gene fusions between two genes, NAB2 and STAT6. All SFTs examined exhibited an in-frame fusion transcript encoding a fusion protein containing the EGR1 interaction domain ...

phs000567 | dbGaP
GenomicsIncrease genome editing efficiency by Cas9 transcriptional activator and histone acetyltransferase activator
Increase genome editing efficiency by Cas9 transcriptional activator and histone acetyltransferase activator
PRJNA827683 | ENA
TranscriptomicsRNAi knock down of the DNA-repair enzyme and transcriptional co-activator APE1 in human HeLa cells
Transcriptional profiling was done following APE1/Ref1 silencing using conditional gene expression knockdown by RNA interference (RNAi) technology in HeLa cell lines. APE1 is a DNA-repair enzyme and transcriptional co-activator. Knockdown leads to cell-growth arrest, apoptosis and impairment in the ...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-MEXP-1315 | biostudies-arrayexpress
TranscriptomicsThe kinase TNIK is an essential activator of Wnt target genes
Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/ß-catenin activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/ß-catenin transcriptional progra...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17623 | biostudies-arrayexpress
TranscriptomicsThe transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells
This SuperSeries is composed of the following subset Series: GSE25265: Genome-wide analysis of the binding pattern of the transcriptional co-activator Cbp. GSE25268: The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells Refer to individual S...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25274 | biostudies-arrayexpress
ProteomicsZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD006074 | Pride
Zbtb48  hela  u2os  knock-out 
GenomicsThe Firre lncRNA acts as a transcriptional activator [PRO-Seq]
The Firre lncRNA acts as a transcriptional activator [PRO-Seq]
PRJNA892152 | ENA
GenomicsSeparation of transcriptional repressor and activator functions in HDAC3 [CUT&TAG]
Separation of transcriptional repressor and activator functions in HDAC3 [CUT&TAG]
PRJNA849807 | ENA
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