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ProteomicsZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD006074 | Pride
Zbtb48  hela  u2os  knock-out 
ProteomicsZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression
CIITA is the master regulator of MHC II genes expression and hence the adaptive immune response. CIITA expression itself is tightly regulated by three cell type-specific promoters, pI, pIII, and by pIV, and can also be induced by IFNg in non-immune cells. While key regulatory elements have been iden...
ORGANISM(S): Homo sapiens (Human) 
2024-12-22 | PXD043134 | Pride
Mhc ii Adaptive immunity B cell Zinc finger Pioneer factor Molecular switch Ciita Zbtb48 
ProteomicsZbtb48 is a regulator of Mtfp1 expression in zebrafish
ZBTB48 (also known as TZAP) is a transcription factor that has previously been reported to bind to telomeres and act as a negative regulator of telomere length in human cell lines. To explore whether transcription factor activity and telomere length regulation are conserved at the organismal level i...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-01-09 | PXD052763 | Pride
Lc-ms/ms 
UnknownZbtb48 is a regulator of Mtfp1 expression in zebrafish.
Not available
S-EPMC11846949 | biostudies-literature
UnknownZBTB48 is a priming factor regulating B-cell-specific CIITA expression.
Not available
S-EPMC11649694 | biostudies-literature
GenomicsZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [ChIP-seq]
ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [ChIP-seq]
PRJNA997297 | ENA
GenomicsZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [FAIRE-seq]
ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [FAIRE-seq]
PRJNA997298 | ENA
UnknownZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.
Not available
S-EPMC5452029 | biostudies-literature
GenomicsZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [RNA-seq]
ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [RNA-seq]
PRJNA997299 | ENA
GenomicsZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator [ChIP-seq]
Here we show that ZBTB48 binds directly both to telomeric as well as to subtelomeric variant repeat sequences. ZBTB48 is found at telomeres of human cancer cells regardless of the mode of telomere maintenance and it acts as a negative regulator of telomere length. In addition to its telomeric functi...
ORGANISM(S): Homo sapiens 
2017-05-11 | GSE96776 | GEO
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