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RNA buffering upon transcriptional distorsion
Integrating omics data with quantification of biological traits provides unparalleled opportunities for discovery of genetic regulators by in silico inference. However, current approaches to analyze genetic-perturbation screens are limited by their reliance on annotation libraries for prioritization...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024258 | Pride
Post-transcriptional buffering of low nascent RNA transcription by Puf5
Gene expression is a dynamic process regulated on several layers starting with transcription, mRNA export, translation and finally, mRNA degradation. While subsequent layers heavily influence each other, it is not clear if the most extreme layers, chromatin architecture and mRNA decay are linked. He...
ORGANISM(S): Saccharomyces cerevisiae 
Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast
Gene-specific transcript buffering revealed by perturbation of coactivator complexes
Translational buffering tunes gene expression in mouse and human
Chip-seq of S. cerevisiae to investigate post-transcriptional buffering of low nascent RNA transcription by Puf5
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